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Mouse Anti-FCN3 Recombinant Antibody (CBXF-0479) (CBMAB-F1435-CQ)

This product is a mouse antibody that recognizes FCN3. The antibody CBXF-0479 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all FCN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0479
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Ficolin 3
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ficolin 3
Introduction
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Entrez Gene ID
8547
UniProt ID
O75636
Alternative Names
Ficolin 3; Collagen/Fibrinogen Domain-Containing Lectin 3 P35; Collagen/Fibrinogen Domain-Containing Protein 3; Hakata Antigen; HAKA1; FCNH;
Research Area
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.
Biological Process
Complement activation Source: UniProtKB
Complement activation, lectin pathway Source: UniProtKB
Defense response to virus Source: UniProtKB
Negative regulation of RNA biosynthetic process Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Recognition of apoptotic cell Source: UniProtKB
Cellular Location
Secreted. Found in blood plasma, bronchus, alveolus and bile duct.
Involvement in disease
Ficolin 3 deficiency (FCN3D):
A disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine.
PTM
The N-terminus is blocked.

Luo, J., Wang, T., Wang, X., Shi, Y., Zhang, Y., Tian, J., & Gong, Y. (2022). Ficolin-3 may act as a tumour suppressor by recognising O-GlcNAcylation site in hepatocellular carcinoma. Medical Hypotheses, 166, 110899.

Oliveira, F. J. F. D., Serra, M. A. A. D. O., Santos, L. H. D., Araújo, M. F. M. D., Silva, R. N. C. D., & Grumach, A. S. (2022). Serum Levels of Ficolin-3 and Mannose-Binding Lectin in Patients with Leprosy and Their Family Contacts in a Hyperendemic Region in Northeastern Brazil. Tropical Medicine and Infectious Disease, 7(5), 71.

Li, Y., You, E. Q., Lin, W. H., Liu, X. N., Shen, D. P., Zhang, X. L., ... & Li, H. M. (2021). Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population. Journal of Clinical Laboratory Analysis, 35(4), e23732.

Catarino, S. J., Andrade, F. A., Bavia, L., Guilherme, L., & Messias-Reason, I. J. (2021). Ficolin-3 in rheumatic fever and rheumatic heart disease. Immunology Letters, 229, 27-31.

Babaha, F., Abolhassani, H., Hamidi Esfahani, Z., Yazdani, R., & Aghamohammadi, A. (2020). A new case of congenital ficolin-3 deficiency with primary immunodeficiency. Expert Review of Clinical Immunology, 16(7), 733-738.

Dadfar, E., Furuhjelm, C., Nilsson, J., Dahle, C., & Garred, P. (2020). Fatal pneumococcus meningitis in a child with complement factor ficolin-3 deficiency. The Journal of Allergy and Clinical Immunology: In Practice, 8(2), 778-779.

Pieczarka, C., Andrade, F. A., Catarino, S. J., Lidani, K. C. F., Bavia, L., Tizzot, R., ... & de Messias-Reason, I. J. (2020). Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis. Autoimmunity, 53(7), 400-407.

Troldborg, A., Steffensen, R., Trendelenburg, M., Hauser, T., Winther, K. G., Hansen, A. G., ... & Thiel, S. (2019). Ficolin-3 deficiency is associated with disease and an increased risk of systemic lupus erythematosus. Journal of Clinical Immunology, 39(4), 421-429.

Pishkhan Dibazar, S., Zavaran Hosseini, A., Yari, F., Fateh, S., & Deyhim, M. R. (2018). Evaluation of Ficolin-3 (FCN3) 1637delC (rs28357092) Frameshift Mutation in Iranian Type 2 Diabetic Subjects. International Journal of Medical Laboratory, 5(4), 264-270.

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For research use only. Not intended for any clinical use.

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