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Mouse Anti-FCRL3 Recombinant Antibody (CBXF-2594) (CBMAB-F0165-CQ)

This product is a mouse antibody that recognizes FCRL3. The antibody CBXF-2594 can be used for immunoassay techniques such as: FC.
See all FCRL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2594
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
NS0-derived recombinant human FCRL3/FcRH3, Arg14-Arg569, Accession # Q96P31
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fc Receptor Like 3
Introduction
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
115352
UniProt ID
Q96P31
Alternative Names
Fc Receptor Like 3; Immune Receptor Translocation-Associated Protein 3; SH2 Domain-Containing Phosphatase Anchor Protein 2; Fc Receptor Homolog 3; IFGP Family Protein 3; FcR-Like Protein 3; HIFGP3; FCRH3; IFGP3;
Research Area
Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366).

Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936).

Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Negative regulation of B cell receptor signaling pathway Source: UniProtKB
Negative regulation of immunoglobulin production Source: UniProtKB
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: UniProtKB
Positive regulation of protein serine/threonine phosphatase activity Source: UniProtKB
Regulation of B cell activation Source: UniProtKB
Regulation of B cell differentiation Source: UniProtKB
Regulation of calcium ion import Source: UniProtKB
Regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease or multiple sclerosis. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Multiple sclerosis is an autoimmune/inflammatory neurodegenerative disease which mainly affects young adults and is characterized by destruction of myelin in the central nervous system.
Topology
Extracellular: 18-573
Helical: 574-594
Cytoplasmic: 595-734
PTM
Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.

Liu, Q. B., Zhou, R. H., & Liu, C. M. (2022). TLR9/FCRL3 regulates B cell viability, apoptosis, and antibody and IL-10 production through ERK1/2, p38, and STAT3 signaling pathways. In Vitro Cellular & Developmental Biology-Animal, 58(8), 702-711.

Zhang, Y., & Sun, D. (2021). Genetic Polymorphisms of FCRL3, NLRP3 and IL2 are Associated with the Risk of Head and Neck Cancer in a Chinese Population. Pharmacogenomics and Personalized Medicine, 14, 1047.

Kalantar, K., Ghandehari, F., Malek-Hosseini, S., Golmoghaddam, H., Rostamzadeh, D., Dabbaghmanesh, M. H., & Amirghofran, Z. (2020). Association of FCRL3 rs7528684 polymorphism with risk of Hashimoto's thyroiditis in Iranian patients. Meta Gene, 24, 100663.

Cui, X., Liu, C. M., & Liu, Q. B. (2020). FCRL3 promotes IL‐10 expression in B cells through the SHP‐1 and p38 MAPK signaling pathways. Cell Biology International, 44(9), 1811-1819.

Zhang, H., He, Y., He, X., Wang, L., Jin, T., & Yuan, D. (2020). Three SNPs of FCRL3 and one SNP of MTMR3 are associated with immunoglobulin A nephropathy risk. Immunobiology, 225(1), 151869.

Zhong, Z., Feng, S., Shi, D., Xu, R., Yin, P., Wang, M., ... & Li, M. (2019). Association of FCRL3 gene polymorphisms with IgA nephropathy in a Chinese Han population. DNA and Cell Biology, 38(10), 1155-1165.

Gu, Z., Shen, Y., Tang, X. Y., Ke, X., Yao, H. B., Hong, S. L., & Kang, H. Y. (2019). Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population. International journal of pediatric otorhinolaryngology, 120, 58-63.

Štefanić, M., Tokić, S., Suver-Stević, M., & Glavaš-Obrovac, L. (2019). Expression of TIGIT and FCRL3 is altered in T cells from patients with distinct patterns of chronic autoimmune thyroiditis. Experimental and Clinical Endocrinology & Diabetes, 127(05), 281-288.

Shahram, F., Kazemi, J., Mahmoudi, M., & Jadali, Z. (2019). Single nucleotide polymorphisms of FCRL3 in Iranian patients with Behcet’s disease. Iranian Journal of Public Health, 48(6), 1133.

Anzengruber, F., Ignatova, D., Schlaepfer, T., Chang, Y. T., French, L. E., Pascolo, S., ... & Guenova, E. (2019). Divergent LAG-3 versus BTLA, TIGIT, and FCRL3 expression in Sézary syndrome. Leukemia & Lymphoma.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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