Sign in or Register
  • Home
  • FCRL6
  • Mouse Anti-FCRL6 Recombinant Antibody (CBXF-2597)

Mouse Anti-FCRL6 Recombinant Antibody (CBXF-2597) (CBMAB-F0173-CQ)

See all FCRL6 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBXF-2597
Application
FC
Immunogen
CHO-derived recombinant human FCRL6/FcRH6, Lys16-Leu312, Accession # Q6DN72
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Fc Receptor Like 6
Introduction
FCRL6 (Fc Receptor Like 6) is a Protein Coding gene. Diseases associated with FCRL6 include Viral Pneumonia and Dental Fluorosis. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding. An important paralog of this gene is FCRL3.
Entrez Gene ID
343413
UniProt ID
Q6DN72
Alternative Names
Fc Receptor Like 6; Fc Receptor Homolog 6; FcR-Like Protein 6; FcRH6; IFGP6; IgSF Type I Transmembrane Receptor;
Research Area
Acts as a MHC class II receptor (PubMed:20519654).

When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8+ T cells (PubMed:17213291, PubMed:18991291).

Does not act as an Fc receptor (PubMed:18991291).
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 20-307
Helical: 308-328
Cytoplasmic: 329-434
PTM
Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2.

Davis, R. S. (2020). Roles for the FCRL6 Immunoreceptor in Tumor Immunology. Frontiers in Immunology, 11, 575175.

Honjo, K., Won, W. J., King, R. G., Ianov, L., Crossman, D. K., Easlick, J. L., ... & Davis, R. S. (2020). Fc Receptor-Like 6 (FCRL6) discloses progenitor B cell heterogeneity that correlates with pre-BCR dependent and independent pathways of natural antibody selection. Frontiers in immunology, 11, 82.

Honjo, K., Won, W. J., King, R. G., Ianov, L., Crossman, D. K., Easlick, J. L., ... & Davis, R. S. (2019). Fc receptor-like 6 (FCRL6) defines pre-BCR dependent and independent pathways of natural antibody selection. bioRxiv, 667345.

Johnson, D. B., Nixon, M. J., Wang, Y., Wang, D. Y., Castellanos, E., Estrada, M. V., ... & Balko, J. M. (2018). Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement. JCI insight, 3(24).

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FCRL6 Recombinant Antibody (CBXF-2597)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry