Sign in or Register   Sign in or Register
  |  

Rabbit Anti-FDFT1 Recombinant Antibody (CBXF-1199) (CBMAB-F0195-CQ)

This product is a rabbit antibody that recognizes FDFT1. The antibody CBXF-1199 can be used for immunoassay techniques such as: WB, IP, IF.
See all FDFT1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXF-1199
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
farnesyl-diphosphate farnesyltransferase 1
Introduction
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
Entrez Gene ID
2222
UniProt ID
P37268
Alternative Names
Farnesyl-Diphosphate Farnesyltransferase 1; FPP:FPP Farnesyltransferase; Squalene Synthase; EC 2.5.1.21; SQS; SS;
Research Area
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway.
Biological Process
Cholesterol biosynthetic process Source: GO_Central
Farnesyl diphosphate metabolic process Source: GO_Central
Steroid biosynthetic process Source: ProtInc
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
An autosomal recessive disorder characterized by profound developmental delay, brain abnormalities, 2/3 syndactyly of the toes, facial dysmorphisms, low total and LDL-cholesterol, and abnormal urine organic acids.

Kanmalar, M., Abdul Sani, S. F., Kamri, N. I. N. B., Said, N. A., Jamil, A. H., Kuppusamy, S., ... & Bradley, D. A. (2022). Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review. Cellular & Molecular Biology Letters, 27(1), 1-20.

Pu, X., Lin, X., Qi, Y., Li, Y., Li, T., Liu, Y., & Wei, D. (2022). Effects of Fdft 1 gene silencing and VD3 intervention on lung injury in hypoxia-stressed rats. Genes & Genomics, 44(10), 1201-1213.

Huang, R., Zhang, C., Wang, X., Zou, X., Xiang, Z., Wang, Z., ... & Hu, H. (2022). Identification of FDFT1 as a potential biomarker associated with ferroptosis in ccRCC. Cancer Medicine.

Huang, C., Wen, Q., Chen, J., Zhong, H., Xiang, X., Xiong, J., & Deng, J. (2022). FDFT1/FGFR2 rearrangement: A newly identified anlotinib-sensitive FGFR2 variant in cholangiocarcinoma. Cancer Treatment and Research Communications, 31, 100568.

Dong, X., Zhu, Y., Wang, S., Luo, Y., Lu, S., Nan, F., ... & Sun, X. (2020). Bavachinin inhibits cholesterol synthesis enzyme FDFT1 expression via AKT/mTOR/SREBP-2 pathway. International Immunopharmacology, 88, 106865.

Lu, J., Zhou, Y., Zheng, X., Chen, L., Tuo, X., Chen, H., ... & Zhao, L. (2020). 20 (S)-Rg3 upregulates FDFT1 via reducing miR-4425 to inhibit ovarian cancer progression. Archives of Biochemistry and Biophysics, 693, 108569.

Weng, M. L., Chen, W. K., Chen, X. Y., Lu, H., Sun, Z. R., Yu, Q., ... & Miao, C. H. (2020). Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression. Nature communications, 11(1), 1-17.

Lin, X., Wang, H., & Pu, X. (2020). Protective mechanism of fdft1 in steroid hormone synthesis pathway in SD rats with acute hypoxic injury. Genes & genomics, 42(11), 1319-1326.

Tüzmen, Ş., Hostetter, G., Watanabe, A., Ekmekçi, C., Carrigan, P. E., Shechter, I., ... & Mousses, S. (2019). Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer. Personalized Medicine, 16(1), 51-65.

Ma, Y. S., Wu, Z. J., Zhang, H. W., Cai, B., Huang, T., Long, H. D., ... & Fu, D. (2019). Dual regulatory mechanisms of expression and mutation involving metabolism-related genes FDFT1 and UQCR5 during CLM. Molecular Therapy-Oncolytics, 14, 172-178.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-FDFT1 Recombinant Antibody (CBXF-1199)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare