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Mouse Anti-FEZF1 Recombinant Antibody (CBXF-1737) (CBMAB-F3272-CQ)

This product is a mouse antibody that recognizes FEZF1. The antibody CBXF-1737 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FEZF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1737
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FEZ Family Zinc Finger 1
Introduction
This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
389549
UniProt ID
A0PJY2
Alternative Names
FEZ Family Zinc Finger 1; Zinc Finger Protein 312B; ZNF312B; FEZ; Fez Family Zinc Finger Protein 1; HH22;
Research Area
Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity).
Biological Process
Axon guidance Source: Ensembl
Cell dedifferentiation Source: Ensembl
Forebrain anterior/posterior pattern specification Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Neuron migration Source: Ensembl
Olfactory bulb development Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: Ensembl
Regulation of neurogenesis Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Hypogonadotropic hypogonadism 22 with or without anosmia (HH22):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).

Sun, Z., Gao, S., Xuan, L., & Liu, X. (2020). Long non‐coding RNA FEZF1‐AS1 induced progression of ovarian cancer via regulating miR‐130a‐5p/SOX4 axis. Journal of Cellular and Molecular Medicine, 24(7), 4275-4285.

Hui, Y., Yang, Y., Li, D., Wang, J., Di, M., Zhang, S., & Wang, S. (2020). LncRNA FEZF1-AS1 modulates cancer stem cell properties of human gastric cancer through miR-363-3p/HMGA2. Cell Transplantation, 29, 0963689720925059.

Luo, L., Zhang, Y., He, H., Chen, C., Zhang, B., & Cai, M. (2020). LncRNA FEZF1-AS1 sponges miR-34a to upregulate Notch-1 in glioblastoma. Cancer management and research, 12, 1827.

Song, H., Li, H., Ding, X., Li, M., Shen, H., Li, Y., ... & Xing, L. (2020). Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis. International journal of oncology, 57(6), 1333-1347.

Cao, Y., Wang, X., & Chen, L. (2020). Knockdown of Fez family zinc finger protein 1 antisense ribonucleic acid 1 (FEZF1-AS1) inhibits invasion and migration of esophageal squamous cell carcinoma cells by blocking JAK2/STAT3 pathway. Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal of Cellular and Molecular Immunology, 36(4), 317-324.

Li, J., Zhao, L. M., Zhang, C., Li, M., Gao, B., Hu, X. H., ... & Wang, G. Y. (2020). The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p. Oncology Research, 28(1), 51.

Zhou, Y., Xu, S., Xia, H., Gao, Z., Huang, R., Tang, E., & Jiang, X. (2019). Long noncoding RNA FEZF1-AS1 in human cancers. Clinica Chimica Acta, 497, 20-26.

Shi, C., Sun, L., & Song, Y. (2019). FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies. Bioscience Reports, 39(6).

Bian, Z., Zhang, J., Li, M., Feng, Y., Wang, X., Zhang, J., ... & Huang, Z. (2018). LncRNA–FEZF1-AS1 Promotes Tumor Proliferation and Metastasis in Colorectal Cancer by Regulating PKM2 SignalingOncogenic Function of FEZF1-AS1 in Colorectal Cancer. Clinical Cancer Research, 24(19), 4808-4819.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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