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Mouse Anti-FGF14 Recombinant Antibody (CBXF-0547) (CBMAB-F1223-CQ)

This product is a mouse antibody that recognizes FGF14. The antibody CBXF-0547 can be used for immunoassay techniques such as: IF.
See all FGF14 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0547
Antibody Isotype
IgG
Application
IF

Basic Information

Immunogen
Synthetic peptide
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10 mM PBS, pH 7.4, 10 mg/ml BSA, 25% glycerol
Preservative
0.03% Proclin 300
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibroblast Growth Factor 14
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
2259
UniProt ID
Q92915
Alternative Names
Fibroblast Growth Factor 14; Fibroblast Growth Factor Homologous Factor 4; FGF-14; FHF-4; FHF4; BA397O8.2; SCA27;
Research Area
Probably involved in nervous system development and function.
Biological Process
Cell-cell signaling Source: ProtInc
JNK cascade Source: MGI
Nervous system development Source: ProtInc
Positive regulation of high voltage-gated calcium channel activity Source: Ensembl
Regulation of postsynaptic membrane potential Source: Ensembl
Regulation of synaptic plasticity Source: Ensembl
Regulation of synaptic vesicle recycling Source: Ensembl
Regulation of voltage-gated sodium channel activity Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Spinocerebellar ataxia 27 (SCA27):
Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits.

Ceroni, F., Osborne, D., Clokie, S., Bax, D. A., Cassidy, E. J., Dunn, M. J., ... & Ragge, N. K. (2022). Analysis of Fibroblast Growth Factor 14 (FGF14) structural variants reveals the genetic basis of the early onset nystagmus locus NYS4 and variable ataxia. European Journal of Human Genetics, 1-7.

Pellerin, D., Danzi, M. C., Wilke, C., Renaud, M., Fazal, S., Dicaire, M. J., ... & Brais, B. (2022). Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia. New England Journal of Medicine.

Dvorak, N. M., Wadsworth, P., Wang, P., Chen, H., Zhou, J., & Laezza, F. (2021). Elucidating the Structural Constituents of Fibroblast Growth Factor 14 that Confer its Modulatory Effects on the Voltage-Gated Sodium Channel 1.6. Biophysical Journal, 120(3), 156a.

Dvorak, N. M., Tapia, C. M., Singh, A. K., Baumgartner, T. J., Wang, P., Chen, H., ... & Laezza, F. (2021). Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na+ Channel 1.6 Enables Isoform-Selective Modulation. International journal of molecular sciences, 22(24), 13541.

Wang, L., Jing, R., Wang, X., Wang, B., Guo, K., Zhao, J., ... & Xuan, X. (2021). A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer’s disease model. Annals of Translational Medicine, 9(12).

Turkowski, K., Herzberg, F., Günther, S., Brunn, D., Weigert, A., Meister, M., ... & Savai, R. (2020). Fibroblast Growth Factor—14 Acts as Tumor Suppressor in Lung Adenocarcinomas. Cells, 9(8), 1755.

Su, T., Huang, L., Zhang, N., Peng, S., Li, X., Wei, G., ... & Xu, L. (2020). FGF14 functions as a tumor suppressor through inhibiting PI3K/AKT/mTOR pathway in colorectal cancer. Journal of Cancer, 11(4), 819.

Sowers, M. L., Di Re, J., Wadsworth, P. A., Shavkunov, A. S., Lichti, C., Zhang, K., & Laezza, F. (2019). Sex-specific proteomic changes induced by genetic deletion of fibroblast growth factor 14 (FGF14), a regulator of neuronal ion channels. Proteomes, 7(1), 5.

Liu, Z., Wadsworth, P., Singh, A. K., Chen, H., Wang, P., Folorunso, O., ... & Zhou, J. (2019). Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1. 6) protein-protein interactions. Bioorganic & medicinal chemistry letters, 29(3), 413-419.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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