Mouse Anti-FGF14 Recombinant Antibody (CBXF-0547) (CBMAB-F1223-CQ)

Name: Mouse Anti-FGF14 Recombinant Antibody (CBXF-0547)
SKU: CBMAB-F1223-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0547

Application

Immunogen

Synthetic peptide

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

10 mM PBS, pH 7.4, 10 mg/ml BSA, 25% glycerol

Preservative

0.03% Proclin 300

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 14

Introduction

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.

Entrez Gene ID

2259

UniProt ID

Q92915

Alternative Names

Fibroblast Growth Factor 14; Fibroblast Growth Factor Homologous Factor 4; FGF-14; FHF-4; FHF4; BA397O8.2; SCA27;

Research Area

Probably involved in nervous system development and function.

Biological Process

Cell-cell signaling Source: ProtInc
JNK cascade Source: MGI
Nervous system development Source: ProtInc
Positive regulation of high voltage-gated calcium channel activity Source: Ensembl
Regulation of postsynaptic membrane potential Source: Ensembl
Regulation of synaptic plasticity Source: Ensembl
Regulation of synaptic vesicle recycling Source: Ensembl
Regulation of voltage-gated sodium channel activity Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Nucleus

Involvement in disease

Spinocerebellar ataxia 27 (SCA27):
Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits.

Ceroni, F., Osborne, D., Clokie, S., Bax, D. A., Cassidy, E. J., Dunn, M. J., ... & Ragge, N. K. (2022). Analysis of Fibroblast Growth Factor 14 (FGF14) structural variants reveals the genetic basis of the early onset nystagmus locus NYS4 and variable ataxia. European Journal of Human Genetics, 1-7.

Pellerin, D., Danzi, M. C., Wilke, C., Renaud, M., Fazal, S., Dicaire, M. J., ... & Brais, B. (2022). Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia. New England Journal of Medicine.

Dvorak, N. M., Wadsworth, P., Wang, P., Chen, H., Zhou, J., & Laezza, F. (2021). Elucidating the Structural Constituents of Fibroblast Growth Factor 14 that Confer its Modulatory Effects on the Voltage-Gated Sodium Channel 1.6. Biophysical Journal, 120(3), 156a.

Dvorak, N. M., Tapia, C. M., Singh, A. K., Baumgartner, T. J., Wang, P., Chen, H., ... & Laezza, F. (2021). Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na+ Channel 1.6 Enables Isoform-Selective Modulation. International journal of molecular sciences, 22(24), 13541.

Wang, L., Jing, R., Wang, X., Wang, B., Guo, K., Zhao, J., ... & Xuan, X. (2021). A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer’s disease model. Annals of Translational Medicine, 9(12).

Turkowski, K., Herzberg, F., Günther, S., Brunn, D., Weigert, A., Meister, M., ... & Savai, R. (2020). Fibroblast Growth Factor—14 Acts as Tumor Suppressor in Lung Adenocarcinomas. Cells, 9(8), 1755.

Su, T., Huang, L., Zhang, N., Peng, S., Li, X., Wei, G., ... & Xu, L. (2020). FGF14 functions as a tumor suppressor through inhibiting PI3K/AKT/mTOR pathway in colorectal cancer. Journal of Cancer, 11(4), 819.

Sowers, M. L., Di Re, J., Wadsworth, P. A., Shavkunov, A. S., Lichti, C., Zhang, K., & Laezza, F. (2019). Sex-specific proteomic changes induced by genetic deletion of fibroblast growth factor 14 (FGF14), a regulator of neuronal ion channels. Proteomes, 7(1), 5.

Liu, Z., Wadsworth, P., Singh, A. K., Chen, H., Wang, P., Folorunso, O., ... & Zhou, J. (2019). Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1. 6) protein-protein interactions. Bioorganic & medicinal chemistry letters, 29(3), 413-419.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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