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Mouse Anti-FGF3 Recombinant Antibody (CBXF-2159) (CBMAB-F1357-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2159
Antibody Isotype
IgG2
Application
IHC, Neut, WB

Basic Information

Immunogen
Human recombinant FGF-3
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibroblast Growth Factor 3
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.
Entrez Gene ID
2248
UniProt ID
P11487
Alternative Names
Fibroblast Growth Factor 3; Fibroblast Growth Factor 3 (Murine Mammary Tumor Virus Integration Site (V-Int-2) Oncogene Homolog); V-INT2 Murine Mammary Tumor Virus Integration Site Oncogene Homolog; Murine Mammary Tumor Virus Integration Site 2, Mouse; Heparin-Binding Growth Factor 3; INT-2 Proto-Oncogene Protein;
Research Area
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Negative regulation of cardiac muscle tissue development Source: BHF-UCL
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of cell migration Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Secreted
Involvement in disease
Deafness with labyrinthine aplasia, microtia and microdontia (LAMM):
Unique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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