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Rabbit Anti-FKBP1A Recombinant Antibody (CBXF-1056) (CBMAB-F0907-CQ)

This product is a rabbit antibody that recognizes FKBP1A. The antibody CBXF-1056 can be used for immunoassay techniques such as: WB, IF.
See all FKBP1A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1056
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FK506 Binding Protein 1A
Introduction
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
Entrez Gene ID
Human2280
Mouse14225
Rat25639
UniProt ID
HumanP62942
MouseP26883
RatQ62658
Alternative Names
FK506 Binding Protein 1A; FK506 Binding Protein 1A, 12kDa; 12 KDa FK506-Binding Protein; Immunophilin FKBP12; PPIase FKBP1A; 12 KDa FKBP; Calstabin-1; EC 5.2.1.8; Rotamase; FKBP-12; FKBP-1A; FKBP12; FKBP1; Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A;
Function
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Biological Process
de novo' protein folding Source: BHF-UCL
Amyloid fibril formation Source: BHF-UCL
Calcium ion transmembrane transport Source: BHF-UCL
Chaperone-mediated protein folding Source: GO_Central
Heart morphogenesis Source: BHF-UCL
Heart trabecula formation Source: BHF-UCL
Negative regulation of phosphoprotein phosphatase activity Source: BHF-UCL
Negative regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of protein ubiquitination Source: BHF-UCL
Protein folding Source: UniProtKB
Protein maturation by protein folding Source: BHF-UCL
Protein peptidyl-prolyl isomerization Source: BHF-UCL
Protein refolding Source: BHF-UCL
Regulation of activin receptor signaling pathway Source: BHF-UCL
Regulation of amyloid precursor protein catabolic process Source: ParkinsonsUK-UCL
Regulation of immune response Source: BHF-UCL
Regulation of protein localization Source: ParkinsonsUK-UCL
Regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
SMAD protein complex assembly Source: BHF-UCL
Supramolecular fiber organization Source: BHF-UCL
T cell activation Source: BHF-UCL
Ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Cellular Location
Cytosol; Sarcoplasmic reticulum membrane

Li, Z., Cui, Y., Duan, Q., Zhang, J., Shao, D., Cao, X., ... & Xu, X. (2022). The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma. International Journal of Molecular Sciences, 23(21), 12797.

Patel, D., Dabhi, A. M., Dmello, C., Seervi, M., Sneha, K. M., Agrawal, P., ... & Kanojia, D. (2022). FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC. Cell Biology International, 46(3), 443-453.

Cai, S., Chen, Z., Tang, H., Meng, S., Tao, L., & Wang, Q. (2022). Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway. International Journal of Molecular Sciences, 23(23), 14935.

Wang, G., Zhao, H., Duan, X., & Ren, Z. (2021). CircRNA pappalysin 1 facilitates prostate cancer development through miR‐515‐5p/FKBP1A axis. Andrologia, 53(11), e14227.

Pedret, A., Catalan, U., Rubió, L., Baiges, I., Herrero, P., Pinol, C., ... & Solà, R. (2021). Phosphoproteomic Analysis and Protein–Protein Interaction of Rat Aorta GJA1 and Rat Heart FKBP1A after Secoiridoid Consumption from Virgin Olive Oil: A Functional Proteomic Approach. Journal of Agricultural and Food Chemistry, 69(5), 1536-1554.

Leng, W., Liu, Q., Zhang, S., Sun, D., & Guo, Y. (2020). LncRNA AFAP1-AS1 modulates the sensitivity of paclitaxel-resistant prostate cancer cells to paclitaxel via miR-195-5p/FKBP1A axis. Cancer Biology & Therapy, 21(11), 1072-1080.

Zhang, Y., Zhang, D., Lv, J., Wang, S., & Zhang, Q. (2019). LncRNA SNHG15 acts as an oncogene in prostate cancer by regulating miR-338-3p/FKBP1A axis. Gene, 705, 44-50.

Wu, Z., Xu, Q., Qiu, X., Xu, L., Jiao, Z., Zhang, M., & Zhong, M. (2019). FKBP1A rs6041749 polymorphism is associated with allograft function in renal transplant patients. European Journal of Clinical Pharmacology, 75, 33-40.

Esch, S., König, S., Bopp, B., Jose, J., Brandt, S., & Hensel, A. (2019). Cryptotanshinone from Salvia miltiorrhiza Roots Reduces Cytokeratin CK1/10 Expression in Keratinocytes by Activation of Peptidyl-prolyl-cis-trans-isomerase FKBP1A. Planta Medica, 85(07), 552-562.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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