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Rabbit Anti-FKBP6 Recombinant Antibody (CBXF-1181) (CBMAB-F0912-CQ)

This product is a rabbit antibody that recognizes FKBP6. The antibody CBXF-1181 can be used for immunoassay techniques such as: WB, IHC-P, FC.
See all FKBP6 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1181
Antibody Isotype
IgG
Application
WB, IHC-P, FC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FK506 Binding Protein 6
Introduction
The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human8468
Mouse94244
Rat288597
UniProt ID
HumanO75344
MouseQ91XW8
RatD3ZQF4
Alternative Names
FK506 Binding Protein 6; Immunophilin FKBP36; FK506 Binding Protein 6, 36kDa; Inactive PPIase FKBP6; 36 KDa FKBP; Rotamase; FKBP36; Inactive Peptidyl-Prolyl Cis-Trans Isomerase FKBP6; Peptidyl-Prolyl Cis-Trans Isomerase FKBP6;
Function
Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
Biological Process
Cell differentiation Source: UniProtKB-KW
DNA methylation involved in gamete generation Source: UniProtKB
Gene silencing by RNA Source: UniProtKB
Meiotic cell cycle Source: UniProtKB
piRNA metabolic process Source: UniProtKB
Positive regulation of viral genome replication Source: AgBase
Protein folding Source: UniProtKB
Protein peptidyl-prolyl isomerization Source: GOC
Spermatogenesis Source: UniProtKB
Cellular Location
Cytosol; Nucleus; Chromosome. Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity).
Involvement in disease
FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease (PubMed:9782077). A father and son with Williams-Beuren syndrome appear to have a common heterozygous deletion that includes FKBP6 gene. However, the haploinsufficiency for FKBP6 does not appear to preclude male fertility (PubMed:15770126).
Defects in FKBP6 may be a cause of azoospermia. A study based on 323 patients with azoospermia or severe oligozoospermia suggested an association between FKBP6 variants and azoospermia (PubMed:17307919). However, other studies suggest that defects in FKBP6 are not a common cause of non-obstructive azoospermia (PubMed:16227348).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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