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Mouse Anti-FLRT1 Recombinant Antibody (4E10) (CBMAB-A3040-LY)

The product is antibody recognizes FLRT1. The antibody 4E10 immunoassay techniques such as: sELISA, ELISA.
See all FLRT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E10
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
FLRT1 (AAH18370, 1 a.a. ~ 674 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
fibronectin leucine rich transmembrane protein 1
Introduction
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq]
Entrez Gene ID
23769
UniProt ID
Q9NZU1
Alternative Names
MGC21624
Function
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.
Biological Process
Cell adhesion Source: UniProtKB-KW
Dendrite development Source: UniProtKB
Fibroblast growth factor receptor signaling pathway Source: UniProtKB
Neuron projection extension Source: UniProtKB
Cellular Location
Secreted; Endoplasmic reticulum membrane; Cell membrane; Cytoplasmic vesicle membrane; Perinuclear region; Focal adhesion; Neuron projection; Cell junction. In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain.
Topology
Extracellular: 21-524
Helical: 525-545
Cytoplasmic: 546-646
PTM
N-glycosylated.
Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases.
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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