Sign in or Register   Sign in or Register
  |  

Mouse Anti-FOSL2 Recombinant Antibody (2B2) (CBMAB-A3073-LY)

The product is antibody recognizes FOSL2. The antibody 2B2 immunoassay techniques such as: WB, ELISA.
See all FOSL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B2
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
FOSL2 (AAH08899, 1 a.a. ~ 122 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FOSL2
Introduction
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq]
Entrez Gene ID
2355
UniProt ID
P15408
Alternative Names
FLJ23306; FRA2
Function
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
Biological Process
Cell death Source: ProtInc
Keratinocyte development Source: Ensembl
Positive regulation of fibroblast proliferation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Ji, C., Hong, X., Lan, B., Lin, Y., He, Y., Chen, J., ... & Lin, S. (2021). Circ_0091581 promotes the progression of hepatocellular carcinoma through targeting miR-591/FOSL2 axis. Digestive Diseases and Sciences, 66, 3074-3085.

Liu, L., & Wang, S. (2020). Long non-coding RNA OIP5-AS1 knockdown enhances CDDP sensitivity in osteosarcoma via miR-377-3p/FOSL2 axis. OncoTargets and therapy, 13, 3853.

Gao, L., Jin, H. J., Zhang, D., & Lin, Q. (2020). Silencing circRNA_001937 may inhibit cutaneous squamous cell carcinoma proliferation and induce apoptosis by preventing the sponging of the miRNA‑597‑3p/FOSL2 pathway. International journal of molecular medicine, 46(5), 1653-1660.

Xu, P., Wang, L., Xie, X., Hu, F., Yang, Q., Hu, R., ... & Xiao, H. (2020). Hsa_circ_0001869 promotes NSCLC progression via sponging miR-638 and enhancing FOSL2 expression. Aging (albany NY), 12(23), 23836.

Li, Z., Liu, Y., Yan, J., Zeng, Q., Hu, Y., Wang, H., ... & Yu, Z. (2020). Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis. Aging (albany NY), 12(3), 2485.

Renoux, F., Stellato, M., Haftmann, C., Vogetseder, A., Huang, R., Subramaniam, A., ... & Distler, O. (2020). The AP1 transcription factor Fosl2 promotes systemic autoimmunity and inflammation by repressing Treg development. Cell reports, 31(13), 107826.

Sarode, P., Zheng, X., Giotopoulou, G. A., Weigert, A., Kuenne, C., Günther, S., ... & Savai, R. (2020). Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer. Science advances, 6(23), eaaz6105.

Chen, X., Wang, Z., Tong, F., Dong, X., Wu, G., & Zhang, R. (2020). lncRNA UCA1 promotes gefitinib resistance as a ceRNA to target FOSL2 by sponging miR-143 in non-small cell lung cancer. Molecular Therapy-Nucleic Acids, 19, 643-653.

Li, Z., Niu, H., Qin, Q., Yang, S., Wang, Q., Yu, C., ... & Chen, X. (2019). lncRNA UCA1 mediates resistance to cisplatin by regulating the miR-143/FOSL2-signaling pathway in ovarian cancer. Molecular Therapy-Nucleic Acids, 17, 92-101.

Li, S., Fang, X. D., Wang, X. Y., & Fei, B. Y. (2018). Fos-like antigen 2 (FOSL2) promotes metastasis in colon cancer. Experimental Cell Research, 373(1-2), 57-61.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FOSL2 Recombinant Antibody (2B2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare