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Mouse Anti-FOXI1 Antibody (1C4) (CBMAB-0381-YC)

Provided herein are mouse monoclonal antibodies against Human FOXI1. The antibody clone 1C4 can be used for immunoassay techniques, such as IP, WB and MA.
See all FOXI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C4
Antibody Isotype
IgG2a
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
forkhead box I1
Introduction
FOXI1 (forkhead box I1) belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. FOXI1 has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Also, FOXI1 may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis.
Entrez Gene ID
2299
UniProt ID
Q12951
Alternative Names
FKHL10; FREAC6; JFJ-3
Function
Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
Embryo development ending in birth or egg hatching Source: UniProtKB
Inner ear morphogenesis Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Morini, A., Drossart, T., Timsit, M. O., Sibony, M., Vasiliu, V., Gimenez-Roqueplo, A. P., ... & Verkarre, V. (2022). Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1. Modern Pathology, 35(3), 352-360.

Yang, Y. Q., Ge, P., Lv, M. Q., Yu, P. F., Liu, Z. G., Zhang, J., ... & Zhou, D. X. (2022). Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis. Ecotoxicology and Environmental Safety, 243, 113999.

Kui, M., Pluznick, J. L., & Zaidman, N. A. (2022). The Transcription Factor Foxi1 Promotes Expression of V-ATPase and Gpr116 in M-1 cells. American Journal of Physiology-Renal Physiology.

Klarov, L. A., Pshennikova, V. G., Romanov, G. P., Cherdonova, A. M., Solovyev, A. V., Teryutin, F. M., ... & Barashkov, N. A. (2022). Analysis of SLC26A4, FOXI1, and KCNJ10 Gene Variants in Patients with Incomplete Partition of the Cochlea and Enlarged Vestibular Aqueduct (EVA) Anomalies. International Journal of Molecular Sciences, 23(23), 15372.

Sun, R., Lü, W., Liu, Z., Yang, Y., Wang, X., Zhao, X., ... & Diao, D. (2021). FOXI1 inhibits gastric cancer cell proliferation by activating miR-590/ATF3 axis via integrating ChIP-seq and RNA-seq data. Progress in biophysics and molecular biology, 163, 34-45.

Tong, K., & Hu, Z. (2021). FOXI1 expression in chromophobe renal cell carcinoma and renal oncocytoma: a study of The Cancer Genome Atlas transcriptome–based outlier mining and immunohistochemistry. Virchows Archiv, 478, 647-658.

Barone, S., Zahedi, K., Brooks, M., Henske, E. P., Yang, Y., Zhang, E., ... & Soleimani, M. (2021). Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex. Proceedings of the National Academy of Sciences, 118(6), e2020190118.

Molnar, A., Horvath, C. A., Czovek, P., Szanto, A., & Kovacs, G. (2019). FOXI1 immunohistochemistry differentiates benign renal oncocytoma from malignant chromophobe renal cell carcinoma. Anticancer Research, 39(6), 2785-2790.

Jin, S., Jiyun, O., Stellabotte, F., & Choe, C. P. (2018). Foxi1 promotes late-stage pharyngeal pouch morphogenesis through ectodermal Wnt4a activation. Developmental biology, 441(1), 12-18.

Enerbäck, S., Nilsson, D., Edwards, N., Heglind, M., Alkanderi, S., Ashton, E., ... & Sayer, J. A. (2018). Acidosis and deafness in patients with recessive mutations in FOXI1. Journal of the American Society of Nephrology, 29(3), 1041-1048.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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