Mouse Anti-FSCN1 Recombinant Antibody (55K-2) (CBMAB-CP0681-LY)
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Target
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Basic Information
Host Animal
Mouse
Clone
55K-2
Application
IHC-P
Immunogen
Monoclonal antibody is produced by immunizing animals with fascin protein purified from HeLa cells.
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
Formulations & Storage [For reference only, actual COA shall prevail!]
Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation
Target
Full Name
Fascin Actin-Bundling Protein 1
Introduction
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Alternative Names
Fascin Actin-Bundling Protein 1; 55 KDa Actin-Bundling Protein; FAN1; P55; SNL; HSN; Fascin Homolog 1; Actin-Bundling Protein (Strongylocentrotus Purpuratus); Singed (Drosophila)-Like (Sea Urchin Fascin Homolog Like);
Function
Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945).
Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945).
Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786).
Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945).
Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).
Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945).
Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786).
Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945).
Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Cell-cell junction assembly Source: UniProtKB
Cell migration Source: UniProtKB
Cell motility Source: UniProtKB
Establishment of apical/basal cell polarity Source: UniProtKB
Establishment or maintenance of cell polarity Source: GO_Central
Microspike assembly Source: UniProtKB
Parallel actin filament bundle assembly Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of lamellipodium assembly Source: UniProtKB
Positive regulation of podosome assembly Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of microvillus assembly Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Cell-cell junction assembly Source: UniProtKB
Cell migration Source: UniProtKB
Cell motility Source: UniProtKB
Establishment of apical/basal cell polarity Source: UniProtKB
Establishment or maintenance of cell polarity Source: GO_Central
Microspike assembly Source: UniProtKB
Parallel actin filament bundle assembly Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of lamellipodium assembly Source: UniProtKB
Positive regulation of podosome assembly Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of microvillus assembly Source: UniProtKB
Cellular Location
Cytoskeleton; Stress fiber; Cytosol; Cell cortex; Filopodium; Invadopodium; Microvillus; Cell junction. Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
PTM
Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).
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For research use only. Not intended for any clinical use.
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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