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FSCN1

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Full Name
Fascin Actin-Bundling Protein 1
Function
Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945).

Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945).

Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786).

Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945).

Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Cell-cell junction assembly Source: UniProtKB
Cell migration Source: UniProtKB
Cell motility Source: UniProtKB
Establishment of apical/basal cell polarity Source: UniProtKB
Establishment or maintenance of cell polarity Source: GO_Central
Microspike assembly Source: UniProtKB
Parallel actin filament bundle assembly Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of lamellipodium assembly Source: UniProtKB
Positive regulation of podosome assembly Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of microvillus assembly Source: UniProtKB
Cellular Location
Cytoskeleton; Stress fiber; Cytosol; Cell cortex; Filopodium; Invadopodium; Microvillus; Cell junction. Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
PTM
Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).

Anti-FSCN1 antibodies

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Target: FSCN1
Host: Mouse
Specificity: Human
Clone: IHC573
Application*: IH
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 6BA11
Application*: WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB48A
Application*: ELISA, IHC
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6BA13
Application*: WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: SPM133
Application*: F, IF, P, WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AT13D2
Application*: WB, IF, F, E
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2032
Application*: E, WB, IH, IF
Target: FSCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1167
Application*: WB, F
Target: FSCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1062
Application*: WB, IP, P, F, IF
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: FSCN1/416
Application*: P, IF, F
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: FSCN1/418
Application*: P, IF, F
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: FSCN1/417
Application*: WB, P, IF, F
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-0914
Application*: P
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXF-0915
Application*: WB, IF
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0917
Application*: WB, IC, P, C, E
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: CBXF-2095
Application*: WB, E, IC, IH
Target: FSCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: CBXF-2082
Application*: WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3731
Application*: P, WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-162404
Application*: P, WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXF-2261
Application*: P, WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse, Chicken
Clone: CBXF-2094
Application*: WB, E
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2418
Application*: E, WB, IF, F
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2673
Application*: E, IH, WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXF-3202
Application*: E, IH
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0916
Application*: E, F, IC, IF, WB
Target: FSCN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 55K-2
Application*: P
Target: FSCN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: D1A8
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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