Mouse Anti-GGCX Recombinant Antibody (CBLG1-090) (CBMAB-G0419-LY)

Name: Mouse Anti-GGCX Recombinant Antibody (CBLG1-090)
SKU: CBMAB-G0419-LY
Rating: 5 (1 reviews)

See all GGCX antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-090

Application

ELISA, IHC, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

0.09% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Gamma-Glutamyl Carboxylase

Introduction

This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Entrez Gene ID

2677

UniProt ID

P38435

Alternative Names

Gamma-Glutamyl Carboxylase; Vitamin K-Dependent Gamma-Carboxylase; Peptidyl-Glutamate 4-Carboxylase; Vitamin K Gamma Glutamyl Carboxylase; EC 4.1.1.90; VKCFD1; GC;

Function

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Biological Process

Blood coagulation Source: ProtInc
Cellular protein modification process Source: ProtInc
Peptidyl-glutamic acid carboxylation Source: GO_Central

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Combined deficiency of vitamin K-dependent clotting factors 1 (VKCFD1):
VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K.
Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency (PXEL-MCFD):
Characterized by hyperlaxity of the skin involving the entire body. Important phenotypic differences with classical PXE include much more severe skin laxity with spreading toward the trunk and limbs with thick, leathery skin folds rather than confinement to flexural areas, and no decrease in visual acuity. Moreover, detailed electron microscopic analyzes revealed that alterations of elastic fibers as well as their mineralization are slightly different from those in classic PXE.

Topology

Cytoplasmic: 2-60
Helical: 61-81
Lumenal: 82-113
Helical: 114-134
Cytoplasmic: 135-136
Helical: 137-157
Lumenal: 158-292
Helical: 293-313
Cytoplasmic: 314-361
Helical: 362-382
Lumenal: 383-758

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-GGCX Recombinant Antibody (CBLG1-090)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-GGCX Recombinant Antibody (CBLG1-1052) (CAT#: CBMAB-G3255-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry