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Mouse Anti-GMPS Recombinant Antibody (CBLG1-148) (CBMAB-G0563-LY)

This product is antibody recognizes GMPS. The antibody CBLG1-148 immunoassay techniques such as: ELISA, IHC, WB.
See all GMPS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-148
Antibody Isotype
IgG1
Application
ELISA, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
guanine monphosphate synthetase
Introduction
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
Entrez Gene ID
8833
UniProt ID
P49915
Alternative Names
Guanine Monophosphate Synthase; Guanine Monophosphate Synthetase; Glutamine Amidotransferase; GMP Synthetase; GMP Synthase; EC 6.3.5.2;
Function
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.
Biological Process
Glutamine metabolic process Source: UniProtKB-KW
GMP biosynthetic process Source: MGI
Purine nucleobase biosynthetic process Source: ProtInc
Purine ribonucleoside monophosphate biosynthetic process Source: Reactome
Cellular Location
Cytoplasm
Involvement in disease
A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.

Nguyen, S., Jovcevski, B., Pukala, T. L., & Bruning, J. B. (2022). Structural insights into the antifungal drug target guanosine monophosphate synthase from Aspergillus fumigatus. Acta Crystallographica Section D: Structural Biology, 78(2), 248-259.

Zhao, P., Song, Z., Wang, Y., Cai, H., Du, X., Li, C., ... & Chen, Z. (2021). The endothelial nitric oxide synthase/cyclic guanosine monophosphate/protein kinase G pathway activates primordial follicles. Aging (Albany NY), 13(1), 1096.

Wang, Q., Guan, Y. F., Hancock, S. E., Wahi, K., van Geldermalsen, M., Zhang, B. K., ... & Holst, J. (2021). Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth. The Journal of Pathology, 254(2), 135-146.

Wang, J., Wu, Y., Li, Y., Wang, Y., Shen, F., Zhou, J., & Chen, Y. (2021). Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway. International Journal of Oncology, 58(4), 1-1.

Huang, F., Abbas, F., Fiaz, S., Imran, M., Yanguo, K., Hassan, W., ... & Chen, X. (2021). Comprehensive characterization of Guanosine monophosphate synthetase in Nicotiana tabacum. Molecular Biology Reports, 1-8.

Wang, Q., Guan, Y. F., Hancock, S. E., Wahi, K., van Geldermalsen, M., Zhang, B. K., ... & Holst, J. (2020). Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo. bioRxiv, 2020-09.

Roberts, R. L., Wallace, M. C., Seinen, M. L., Van Bodegraven, A. A., Krishnaprasad, K., Jones, G. T., ... & Barclay, M. L. (2018). Nonsynonymous polymorphism in guanine monophosphate synthetase is a risk factor for unfavorable thiopurine metabolite ratios in patients with inflammatory bowel disease. Inflammatory Bowel Diseases, 24(12), 2606-2612.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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