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Rabbit Anti-IAV H1N1 HA Recombinant Antibody (CBMW-H1158) (CBMAB-V208-1320-FY)


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Summary

Host Animal
Rabbit
Specificity
IAV
Clone
CBMW-H1158
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant Influenza H1N1 (A/California/04/2009) Hemagglutinin/HA
Specificity
IAV
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
Influenza A virus causes influenza in birds and some mammals, and is the only species of the Alphainfluenzavirus genus of the Orthomyxoviridae family of viruses.
UniProt ID
C3W5S1
Alternative Names
H1N1 HA; Influenza A virus H1N1; H1N1; HA; Hemagglutinin
Function
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Biological Process
Clathrin-dependent endocytosis of virus by host cell Source: UniProtKB-UniRule
Fusion of virus membrane with host endosome membrane Source: UniProtKB-UniRule
Fusion of virus membrane with host plasma membrane Source: InterPro
Viral budding from plasma membrane Source: UniProtKB-UniRule
Virion attachment to host cell Source: UniProtKB-KW
Cellular Location
Virion membrane; Host apical cell membrane. Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Topology
Extracellular: 18-528
Helical: 529-549
Cytoplasmic: 550-565
PTM
Palmitoylated.
In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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