Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-IAV H5N1 M1 (AA 1-252) Recombinant Antibody (CBMW-H2015) (CBMAB-V208-2225-FY)


See all IAV H5N1 M1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
IAV H5N1
Clone
CBMW-H2015
Antibody Isotype
IgG2a
Application
ELISA, IF, IP, WB

Basic Information

Immunogen
Recombinant protein of M1 from influenza A (A/Thailand/1 (KAN- 1)/2004(H5N1)) protein (AA 1-252)
Specificity
IAV H5N1
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-252

Target

Introduction
Influenza A virus causes influenza in birds and some mammals, and is the only species of the Alphainfluenzavirus genus of the Orthomyxoviridae family of viruses.
Alternative Names
Influenza A Virus H5N1 M1
Function
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
Biological Process
Pore formation by virus in membrane of host cell Source: UniProtKB-UniRule
Protein complex oligomerization Source: UniProtKB-UniRule
Suppression by virus of host autophagy Source: UniProtKB-UniRule
Cellular Location
Virion membrane; Host apical cell membrane. Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Topology
Virion surface: 1-22
Helical: 23-43
Intravirion: 44-97
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IAV H5N1 M1 (AA 1-252) Recombinant Antibody (CBMW-H2015)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry