Sign in or Register   Sign in or Register
  |  

Mouse Anti-IL31RA Recombinant Antibody (3A10) (CBMAB-A4405-LY)

The product is antibody recognizes IL31RA. The antibody 3A10 immunoassay techniques such as: WB, ELISA.
See all IL31RA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
IL31RA (NP_620586, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Interleukin 31 Receptor A
Introduction
IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM
Entrez Gene ID
133396
UniProt ID
M0R4P7
Alternative Names
CRL; CRL3; GLM-R; GLMR; GPL; IL-31RA; MGC125346; PRO21384
Function
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700).
May function in skin immunity (PubMed:15184896).
Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity).
Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).
Biological Process
Acute inflammatory response to antigenic stimulusIEA:Ensembl
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response1 PublicationNAS:UniProtKB
Defense response to other organismIEA:Ensembl
Glandular epithelial cell differentiationIEA:Ensembl
Homeostatic process1 PublicationNAS:UniProtKB
Macrophage differentiation1 PublicationNAS:UniProtKB
MAPK cascade1 PublicationNAS:UniProtKB
Monocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of apoptotic process1 PublicationNAS:UniProtKB
Negative regulation of macrophage activation1 PublicationNAS:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIEP:UniProtKB
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIEP:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway1 PublicationNAS:UniProtKB
Cellular Location
Cell membrane; Cell junction, synapse, presynaptic cell membrane; Cell projection, axon
Involvement in disease
Amyloidosis, primary localized cutaneous, 2 (PLCA2):
A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
Topology
Extracellular: 20-519
Helical: 520-540
Cytoplasmic: 541-732
PTM
N-glycosylated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IL31RA Recombinant Antibody (3A10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare