Rat Anti-IL36G Recombinant Antibody (A563) (CBMAB-AP3927LY)

Name: Rat Anti-IL36G Recombinant Antibody (A563)
SKU: CBMAB-AP3927LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

A563

Application

ICC, IHC, IP, WB

Immunogen

His5~Lys149

Specificity

Mouse

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 36 Gamma

Introduction

The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Entrez Gene ID

215257

UniProt ID

Q8R460

Alternative Names

Interleukin 36 Gamma

Function

MAL621Mu21

Biological Process

Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIBA:GO_Central
Innate immune responseIEA:UniProtKB-KW
Positive regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm; Secreted. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.

PTM

N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold) (PubMed:21965679).
Proteolytically cleaved by cathepsin CTSG (PubMed:30804664).

Moreira, C. R., de Alcântara, C. C., Flauzino, T., Martin, L. M. M., Lozovoy, M. A. B., Reiche, E. M. V., & Simão, A. N. C. (2023). IL36G genetic variant is independently associated with susceptibility, severity and joint involvement in psoriasis. Molecular Immunology, 159, 69-75.

Merleev, A., Ji-Xu, A., Toussi, A., Tsoi, L. C., Le, S. T., Luxardi, G., ... & Maverakis, E. (2022). Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G. JCI insight, 7(16).

Lu, Y. W., Chen, Y. J., Shi, N., Yang, L. H., Wang, H. M., Dong, R. J., ... & Li, Y. Y. (2022). IL36G is associated with cutaneous antiviral competence in psoriasis. Frontiers in Immunology, 13, 971071.

Furue, K., Ito, T., Tanaka, Y., Yumine, A., Hashimoto-Hachiya, A., Takemura, M., ... & Furue, M. (2019). Cyto/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon. Journal of dermatological science, 94(1), 244-251.

Traks, T., Keermann, M., Prans, E., Karelson, M., Loite, U., Kõks, G., ... & Kingo, K. (2019). Polymorphisms in IL36G gene are associated with plaque psoriasis. BMC Medical Genetics, 20, 1-8.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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