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Mouse Anti-IMMT Recombinant Antibody (CBFYM-1152) (CBMAB-M1309-FY)

This product is mouse antibody that recognizes IMMT. The antibody CBFYM-1152 can be used for immunoassay techniques such as: ELISA, IHC.
See all IMMT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1152
Antibody Isotype
IgG2a
Application
ELISA, IHC

Basic Information

Immunogen
Human mitochondrial membrane preparation
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
inner membrane protein, mitochondrial (mitofilin)
Introduction
IMMT is a Protein Coding gene. Diseases associated with IMMT include Gracile Syndrome and Melanoma-Associated Retinopathy.
Entrez Gene ID
UniProt ID
Alternative Names
Inner Membrane Mitochondrial Protein
Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180).
Biological Process
Cristae formationManual Assertion Based On ExperimentIMP:UniProtKB
Iinner mitochondrial membrane organization1 PublicationIC:UniProtKB
Mitochondrial calcium ion homeostasisIEA:Ensembl
Cellular Location
Mitochondrion inner membrane; Mitochondrion
Topology
Mitochondrial matrix: 34-45
Helical: 46-64
Mitochondrial intermembrane: 65-758

Lin, H. Y., Wu, H. J., & Chu, P. Y. (2023). Multi-omics and experimental analysis unveil theragnostic value and immunological roles of inner membrane mitochondrial protein (IMMT) in breast cancer. Journal of Translational Medicine, 21(1), 189.

Chen, C. C., Chu, P. Y., & Lin, H. Y. (2023). Supervised learning and multi-omics integration reveals clinical significance of Inner Membrane Mitochondrial Protein (IMMT) in prognostic prediction, tumor immune microenvironment and precision medicine for kidney renal clear cell carcinoma. International Journal of Molecular Sciences, 24(10), 8807.

Rockfield, S. M., Turnis, M. E., Rodriguez-Enriquez, R., Bathina, M., Ng, S. K., Pelletier, S., ... & Opferman, J. T. (2023). Inducible genetic ablation of Immt induces a lethal disruption of the MICOS complex. bioRxiv, 2023-08.

Wang, J., Zhang, Y., Sun, L., & Liu, Y. (2023). IMMT promotes hepatocellular carcinoma formation via PI3K/AKT/mTOR pathway. Oncologie, (0).

Li, Q., Nan, D., Rao, C., Tang, Z., Yang, W., Wu, P., ... & Mao, X. (2023). Burkholderia pseudomallei BipD hijacks host KLHL9/KLHL13/CUL3 E3 ligase to ubiquitinate IMMT that initiates mitophagy to evade killing.

Marco‐Hernández, A. V., Tomás‐Vila, M., Montoya‐Filardi, A., Barranco‐González, H., Vilchez Padilla, J. J., Azorín, I., ... & Martínez‐Castellano, F. (2022). Mitochondrial developmental encephalopathy with bilateral optic neuropathy related to homozygous variants in IMMT gene. Clinical Genetics, 101(2), 233-241.

Dwari, R. K., Sarangi, C. K., Mustakim, S. M., Dash, B., Tripathy, B. C., Ghosh, M. K., & Basu, S. (2020). R&D efforts of CSIR-IMMT toward solving some issues related to Aluminum production. Journal of Sustainable Metallurgy, 6, 9-17.

Hiyoshi, Y., Sato, Y., Ichinoe, M., Nagashio, R., Hagiuda, D., Kobayashi, M., ... & Naoki, K. (2019). Prognostic significance of IMMT expression in surgically‐resected lung adenocarcinoma. Thoracic cancer, 10(11), 2142-2151.

Pérez-Ramírez, M., García-Méndez, A., Siordia-Reyes, A. G., Chavarría, A., Gómez, C., & García-Hernández, N. (2019). Pediatric ependymoma: GNAO1, ASAH1, IMMT and IPO7 protein expression and 5-year prognosis correlation. Clinical Neurology and Neurosurgery, 186, 105488.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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