Mouse Anti-IRF7 Recombinant Antibody (A659) (CBMAB-AP4027LY)

Interferon Regulatory Factor 7

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

Interferon Regulatory Factor 7

11-MIRF-7H

Cellular response to DNA damage stimulusManual Assertion Based On ExperimentTAS:UniProtKB
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Establishment of viral latencyManual Assertion Based On ExperimentTAS:UniProtKB
Immune system processManual Assertion Based On ExperimentIBA:GO_Central
Immunoglobulin mediated immune responseIEA:Ensembl
Innate immune responseManual Assertion Based On ExperimentTAS:UniProtKB
MDA-5 signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of macrophage apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interferon-alpha productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of type I interferon-mediated signaling pathwayIEA:Ensembl
Regulation of adaptive immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of immune responseManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of monocyte differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of MyD88-dependent toll-like receptor signaling pathwayISS:UniProtKB
Regulation of MyD88-independent toll-like receptor signaling pathwayISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of type I interferon productionManual Assertion Based On ExperimentTAS:UniProtKB
Response to virusManual Assertion Based On ExperimentTAS:UniProtKB
Type I interferon signaling pathwayIEA:Ensembl

Cytoplasm; Nucleus. The phosphorylated and active form accumulates selectively in the nucleus.

Immunodeficiency 39 (IMD39):
A primary immunodeficiency causing severe, life-threatening acute respiratory distress upon infection with H1N1 influenza A.

Acetylation inhibits its DNA-binding ability and activity.
In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1.
TRAF6-mediated ubiquitination is required for IRF7 activation (By similarity).
TRIM35 mediates IRF7 'Lys-48'-linked polyubiquitination and subsequent proteasomal degradation (PubMed:25907537).
Ubiquitinated by UBE3C, leading to its degradation (PubMed:21167755).
Sumoylated by TRIM28, which inhibits its transactivation activity.
(Microbial infection) Cleaved and inactivated by the protease 3C of enterovirus 71 allowing the virus to disrupt the host type I interferon production.
(Microbial infection) Cleaved and inactivated by the protease 3C of human enterovirus 68D (EV68) allowing the virus to disrupt the host type I interferon production.
'Lys-48'-linked polyubiquitination and subsequent proteasomal degradation is NMI-dependent in response to Sendai virus infection.