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Rabbit Anti-KCNK4 Recombinant Antibody (EG1766) (CBMAB-EN2105-LY)

The product is antibody recognizes KCNK4. The antibody EG1766 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all KCNK4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1766
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human KCNK4.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium two pore domain channel subfamily K member 4
Introduction
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802.
Entrez Gene ID
Human50801
Mouse16528
UniProt ID
HumanQ9NYG8
MouseO88454
Alternative Names
FHEIG; TRAAK; K2p4.1; TRAAK1
Function
Voltage-insensitive potassium channel (PubMed:22282805).
Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:30290154).
Channel opening is triggered by raising the intracellular pH to basic levels (By similarity).
The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity).
Plays a role in the perception of pain caused by heat (By similarity).
Plays a role in the sensory perception of pain caused by pressure (By similarity).
Biological Process
Cellular response to alkaline pHISS:UniProtKB
Cellular response to fatty acidManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to mechanical stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to temperature stimulusISS:UniProtKB
Detection of mechanical stimulus involved in sensory perception of touchISS:UniProtKB
MemoryIEA:Ensembl
Potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Sensory perception of painISS:UniProtKB
Sensory perception of temperature stimulusISS:UniProtKB
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Facial dysmorphism, hypertrichosis, epilepsy, intellectual and developmental delay, and gingival overgrowth syndrome (FHEIG):
An autosomal dominant syndrome characterized by delayed motor and intellectual development, poor speech, seizures, generalized hypertrichosis and facial dysmorphic features, including hypotonic facies, bitemporal narrowing, micrognathia, deep-set eyes, bushy eyebrows and long eyelashes, low-set ears, short deep philtrum, gingival overgrowth, prominent upper and lower vermilion, and everted upper lip.
Topology
Cytoplasmic: 1-3
Helical: 4-24
Extracellular: 25-87
Helical: 88-109
Extracellular: 110-117
Helical: 118-150
Cytoplasmic: 151-172
Helical: 173-194
Extracellular: 195-199
Helical: 200-219
Extracellular: 220-233
Helical: 234-260
Cytoplasmic: 261-393
PTM
N-glycosylated.

Yan, H. J., He, Y. Y., Jin, L., Guo, Q., Zhou, J. H., & Luo, S. (2023). Expanding the phenotypic spectrum of KCNK4: From syndromic neurodevelopmental disorder to rolandic epilepsy. Frontiers in Molecular Neuroscience, 15, 1081097.

Huang, K., Chen, X., Geng, Z., Xiong, X., Cong, Y., Pan, X., ... & Jia, X. (2023). LncRNA SLC25A21-AS1 increases the chemosensitivity and inhibits the progression of ovarian cancer by upregulating the expression of KCNK4. Functional & Integrative Genomics, 23(2), 110.

Elhossini, R. M., Sayed, I. M., Hellal, U. S., Mahmoud, S. A., Aglan, M. S., Hassib, N. F., & Abdel‐Hamid, M. S. (2023). A recurrent KCNK4 variant in a dominant pedigree with hypertrichosis and gingival fibromatosis syndrome: Variable phenotypic expressivity and insights on patients' dental management. American Journal of Medical Genetics Part A.

Gripp, K. W., Smithson, S. F., Scurr, I. J., Baptista, J., Majumdar, A., Pierre, G., ... & Kutsche, K. (2021). Syndromic disorders caused by gain-of-function variants in KCNH1, KCNK4, and KCNN3—A subgroup of K+ channelopathies. European Journal of Human Genetics, 29(9), 1384-1395.

Mariani, P., Zhurakivska, K., Santoro, R., Laino, G., Russo, D., & Laino, L. (2021). Hereditary gingival fibromatosis associated with the missense mutation of the KCNK4 gene. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 131(6), e175-e182.

Napoli, G. (2020). Functional studies of human K+ channels KCNH1 and KCNK4 and their role in human pathogenesis.

Bauer, C. K., Calligari, P., Radio, F. C., Caputo, V., Dentici, M. L., Falah, N., ... & Tartaglia, M. (2018). Mutations in KCNK4 that affect gating cause a recognizable neurodevelopmental syndrome. The American Journal of Human Genetics, 103(4), 621-630.

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For research use only. Not intended for any clinical use.

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