Mouse Anti-KLF13 Recombinant Antibody (1D3) (CBMAB-K1068-LY)

This product is antibody recognizes KLF13. The antibody 1D3 immunoassay techniques such as: WB, ELISA.
See all KLF13 antibodies

Published Data

Fig.1 MiR-125b-5p represses pro-apoptotic bak1 and klf13.

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Human

Clone

1D3

Antibody Isotype

IgG2a, κ

Application

WB, ELISA

Basic Information

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Kruppel-like factor 13

Introduction

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

Entrez Gene ID

Human	51621
Mouse	50794
Rat	499171

UniProt ID

Human	Q9Y2Y9
Mouse	Q9JJZ6
Rat	D3ZVI8

Function

Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.

Biological Process

Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of erythrocyte differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus

PTM

Phosphorylated.

References

Bernhardt, C., Sock, E., Fröb, F., Hillgärtner, S., Nemer, M., & Wegner, M. (2022). KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF. Nucleic Acids Research, 50(20), 11509-11528.

Chen, C. C., Xie, X. M., Zhao, X. K., Zuo, S., & Li, H. Y. (2022). Krüppel-like factor 13 promotes HCC progression by transcriptional regulation of HMGCS1-mediated cholesterol synthesis. Journal of Clinical and Translational Hepatology, 10(6), 1125.

Ávila-Mendoza, J., Subramani, A., Sifuentes, C. J., & Denver, R. J. (2020). Molecular mechanisms for Krüppel-like factor 13 actions in hippocampal neurons. Molecular neurobiology, 57(9), 3785-3802.

Li, W., Li, B., Li, T., Zhang, E., Wang, Q., Chen, S., & Sun, K. (2020). Identification and analysis of KLF13 variants in patients with congenital heart disease. BMC Medical Genetics, 21(1), 1-8.

Wu, R., Yun, Q., Zhang, J., & Bao, J. (2019). Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion. OncoTargets and therapy, 12, 1509.

Wang, Q., Peng, R., Wang, B., Wang, J., Yu, W., Liu, Y., & Shi, G. (2018). Transcription factor KLF13 inhibits AKT activation and suppresses the growth of prostate carcinoma cells. Cancer Biomarkers, 22(3), 533-541.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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