Sign in or Register   Sign in or Register
  |  

Rabbit Anti-LXN Recombinant Antibody (CBFYE-1498) (CBMAB-E2131-FY)

This product is rabbit antibody that recognizes LXN. The antibody CBFYE-1498 can be used for immunoassay techniques such as: ELISA, WB.
See all LXN antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYE-1498
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant Human Latexin/LXN Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
latexin
Introduction
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases.
Entrez Gene ID
56925
UniProt ID
Q9BS40
Alternative Names
ECI; TCI
Function
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
Biological Process
Detection of temperature stimulus involved in sensory perception of painIEA:Ensembl
Inflammatory responseIEA:UniProtKB-KW
Cellular Location
Nucleus
Cytoplasm
In nuclear speckles. Relocalizes to the cytoplasm during cell division.

Li, X., Wan, H., Tian, Y., Wang, J., Xu, S., Huang, K., ... & Chen, M. (2023). Covalent organic framework-based immunosensor to detect plasma Latexin reveals novel biomarker for coronary artery diseases. Analytica Chimica Acta, 1284, 341993.

Zhang, C., Cui, X., Liu, Y., Wang, F., Signer, R., Nattamai, K., ... & Liang, Y. (2023). Latexin deletion protects against radiation-induced hematopoietic damages via selective activation of Bcl-2 prosurvival pathway. Haematologica, 108(12), 3464.

Cui, X., Zhang, C., Wang, F., Zhao, X., Wang, S., Liu, J., ... & Liang, Y. (2023). Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1. Cell reports, 42(3).

Zaza, G., Neri, F., Bruschi, M., Granata, S., Petretto, A., Bartolucci, M., ... & Furian, L. (2023). Proteomics reveals specific biological changes induced by the normothermic machine perfusion of donor kidneys with a significant up-regulation of Latexin. Scientific Reports, 13(1), 5920.

Kan, S., Li, R., Tan, Y., Yang, F., Xu, S., Wang, L., ... & Chen, M. (2022). Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet. Cell Death & Disease, 13(2), 175.

Kazama, K., Liu, W., Zhang, C., Sun, X., & Sun, J. (2021). Smooth Muscle-Specific Latexin Deficiency Prevents Platelet-Derived Growth Factor-Mediated Vascular Smooth Muscle Cell Phenotypic Switch and Neointimal Formation. Circulation, 144(Suppl_1), A12453-A12453.

He, G., Kan, S., Xu, S., Sun, X., Li, R., Shu, W., & Chen, M. (2021). LXN deficiency regulates cytoskeleton remodelling by promoting proteolytic cleavage of Filamin A in vascular endothelial cells. Journal of Cellular and Molecular Medicine, 25(14), 6815-6827.

Li, Y., Huang, B., Yang, H., Kan, S., Yao, Y., Liu, X., ... & Chen, M. (2020). Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway. Scientific Reports, 10(1), 9868.

Zhang, C., Fondufe-Mittendorf, Y. N., Wang, C., Chen, J., Cheng, Q., Zhou, D., ... & Liang, Y. (2020). Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. haematologica, 105(3), 573.

Seed, R. I., Taurozzi, A. J., Wilcock, D. J., Nappo, G., Erb, H. H., Read, M. L., ... & Collins, A. T. (2019). The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy. Scientific reports, 9(1), 5120.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-LXN Recombinant Antibody (CBFYE-1498)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare