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Mouse Anti-MAP1B Recombinant Antibody (CBFYM-1378) (CBMAB-M1537-FY)

This product is mouse antibody that recognizes MAP1B. The antibody CBFYM-1378 can be used for immunoassay techniques such as: IF, IHC-P.
See all MAP1B antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Human, Rat
Clone
CBFYM-1378
Antibody Isotype
IgG1
Application
IF, IHC-P

Basic Information

Immunogen
Purified bovine brain MAPs
Specificity
Cattle, Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 0.2% BSA
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MICROTUBULE ASSOCIATED PROTEIN 1B
Introduction
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system.
Entrez Gene ID
Human4131
Cattle514739
Rat29456
UniProt ID
HumanP46821
CattleF1N1S2
RatP15205
Alternative Names
Microtubule Associated Protein 1B; Protein Phosphatase 1, Regulatory Subunit 102; Microtubule-Associated Protein 1B; PPP1R102; FUTSCH; MAP-1B; MAP5
Function
Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity).
Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.
Biological Process
Axon extensionManual Assertion Based On ExperimentTAS:ARUK-UCL
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to growth factor stimulusIEA:Ensembl
Cellular response to peptide hormone stimulusIEA:Ensembl
Dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Developmental maturationIEA:Ensembl
Establishment of monopolar cell polarityIEA:Ensembl
Induction of synaptic plasticity by chemical substanceIEA:Ensembl
Microtubule bundle formationIEA:Ensembl
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrion transport along microtubuleIEA:Ensembl
Negative regulation of intracellular transportIEA:Ensembl
Negative regulation of microtubule depolymerizationIEA:Ensembl
Neuron migrationManual Assertion Based On ExperimentTAS:ARUK-UCL
Odontoblast differentiationManual Assertion Based On ExperimentIDA:GO_Central
Peripheral nervous system axon regenerationIEA:Ensembl
Positive regulation of axon extensionIEA:Ensembl
Positive regulation of microtubule polymerizationIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Regulation of microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Response to carbohydrateIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to inorganic substanceIEA:Ensembl
Response to insecticideIEA:Ensembl
Response to mechanical stimulusIEA:Ensembl
Response to vitamin AIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Synapse assemblyIEA:Ensembl
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm
Cell junction, synapse
Cell projection, dendritic spine
Colocalizes with DAPK1 in the microtubules and cortical actin fibers.
MAP1 light chain LC1
Cytoplasm
Involvement in disease
Periventricular nodular heterotopia 9 (PVNH9):
A form of periventricular nodular heterotopia, a disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches. PVNH9 is an autosomal dominant disorder with incomplete penetrance, characterized by impaired intellectual development, cognitive defects, learning disabilities, and behavior abnormalities. Some patients develop seizures.
PTM
LC1 is generated from MAP1B by proteolytic processing.
S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction.

Guo, Y., Shen, M., Dong, Q., Méndez-Albelo, N. M., Huang, S. X., Sirois, C. L., ... & Zhao, X. (2023). Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway. Nature Communications, 14(1), 3801.

Su, P., Tian, Y., Yin, C., Wang, X., Li, D., Yang, C., ... & Qian, A. (2022). MACF1 promotes osteoblastic cell migration by regulating MAP1B through the GSK3beta/TCF7 pathway. Bone, 154, 116238.

Long, J. Y., Jiang, W., Xia, H. B., Fu, J. Y., Lu, P., Hu, F., ... & Long, Y. S. (2020). FMRP-absence-induced up-regulation of hypothalamic MAP1B expression decreases AgRP level linking with reduces in food intake and body weight. Neurochemistry International, 140, 104847.

Cui, L., Zheng, J., Zhao, Q., Chen, J. R., Liu, H., Peng, G., ... & Guan, M. X. (2020). Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss. JCI insight, 5(23).

Jitprapaikulsan, J., Klein, C. J., Pittock, S. J., Gadoth, A., McKeon, A., Mills, J. R., & Dubey, D. (2019). Phenotypic presentations of paraneoplastic neuropathies associated with MAP1B-IgG. Journal of Neurology, Neurosurgery & Psychiatry.

Julca, D. M., Diaz, J., Berger, S., & Leon, E. (2019). MAP1B related syndrome: Case presentation and review of literature. American Journal of Medical Genetics Part A, 179(9), 1703-1708.

Solé, L., Wagnon, J. L., Akin, E. J., Meisler, M. H., & Tamkun, M. M. (2019). The MAP1B binding domain of Nav1. 6 is required for stable expression at the axon initial segment. Journal of Neuroscience, 39(22), 4238-4251.

Auburger, G., Gispert, S., Torres-Odio, S., Jendrach, M., Brehm, N., Canet-Pons, J., ... & Sen, N. E. (2019). SerThr-PhosphoProteome of brain from aged PINK1-KO+ A53T-SNCA mice reveals pT1928-MAP1B and pS3781-ANK2 deficits, as hub between autophagy and synapse changes. International journal of molecular sciences, 20(13), 3284.

Shi, Q., Lin, Y. Q., Saliba, A., Xie, J., Neely, G. G., & Banerjee, S. (2019). Tubulin polymerization promoting protein, ringmaker, and MAP1B homolog futsch coordinate microtubule organization and synaptic growth. Frontiers in cellular neuroscience, 13, 192.

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For research use only. Not intended for any clinical use.

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