Mouse Anti-MAPK13 Recombinant Antibody (A1001) (CBMAB-AP11654LY)

Name: Mouse Anti-MAPK13 Recombinant Antibody (A1001)
SKU: CBMAB-AP11654LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A1001

Application

ELISA, WB

Immunogen

Fusion protein of MAPK13

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Mitogen-Activated Protein Kinase 13

Introduction

This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Entrez Gene ID

Human	5603
Mouse	26415

UniProt ID

Human	O15264
Mouse	Q9Z1B7

Alternative Names

Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase P38 Delta; Stress-Activated Protein Kinase 4; MAP Kinase P38 Delta; MAP Kinase 13; EC 2.7.11.24; MAPK 13;

Function

E-AB-27512

Biological Process

Cell cycleIEA:UniProtKB-KW
Cellular response to anisomycinManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to hydrogen peroxideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to interleukin-1Manual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to sodium arseniteManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to sorbitolManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to UVManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Response to osmotic stressManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Cytosol
Nucleus

PTM

Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.

Keeler, S. P., Wu, K., Zhang, Y., Mao, D., Li, M., Iberg, C. A., ... & Holtzman, M. J. (2023). A new MAPK13-guided inhibitor for respiratory inflammation and mucus production. bioRxiv, 2023-05.

Keeler, S. P., Wu, K., Zhang, Y., Mao, D., Li, M., Iberg, C. A., ... & Holtzman, M. J. (2023). A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production. American Journal of Physiology-Lung Cellular and Molecular Physiology, 325(6), L726-L740.

Kim, J., Chun, Y., Ramirez, C. B., Hoffner, L. A., Jung, S., Jang, K. H., ... & Lee, G. (2023). MAPK13 stabilization via m6A mRNA modification limits anticancer efficacy of rapamycin. Journal of Biological Chemistry, 299(9).

Kim, J., Chun, Y., Ramirez, C. B., Hoffner, L. A., Jung, S., Jang, K. H., ... & Lee, G. (2022). MAPK13 stabilization via m6A modification limits anti-cancer efficacy of rapamycin. bioRxiv, 2022-08.

Liu, Y., Chang, Y., & Cai, Y. (2020). circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis. Aging (Albany NY), 12(8), 6774.

Zheng, L., Han, X., Hu, Y., Zhao, X., Yin, L., Xu, L., ... & Peng, J. (2019). Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis. Pharmacological Research, 139, 431-439.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

MAPK13 Matched Antibody Pair (716) (CAT#: APMAB-716LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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