Mouse Anti-MTM1 Recombinant Antibody (1C10) (CBMAB-A5665-LY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PubMed:9537414).
Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PubMed:14722070).
Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PubMed:21135508).
Plays a role in mitochondrial morphology and positioning (PubMed:21135508).
Required for skeletal muscle maintenance but not for myogenesis (PubMed:21135508).
In skeletal muscles, stabilizes MTMR12 protein levels (PubMed:23818870).
Intermediate filament organization Source: UniProtKB
Mitochondrion distribution Source: UniProtKB
Mitochondrion morphogenesis Source: UniProtKB
Muscle cell cellular homeostasis Source: GO_Central
Negative regulation of autophagosome assembly Source: GO_Central
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
Negative regulation of protein kinase B signaling Source: Ensembl
Negative regulation of TOR signaling Source: Ensembl
Phosphatidylinositol biosynthetic process Source: Reactome
Phosphatidylinositol dephosphorylation Source: UniProtKB
Positive regulation of skeletal muscle tissue growth Source: Ensembl
Protein dephosphorylation Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of vacuole organization Source: UniProtKB
Cell membrane
Cytoplasm
Endosome
Late endosome
Other locations
filopodium
ruffle
sarcomere
Note: Localizes as a dense cytoplasmic network (PubMed:11001925). Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles (PubMed:12118066). Predominantly located in the cytoplasm following interaction with MTMR12 (PubMed:12847286). Recruited to the late endosome following EGF stimulation (PubMed:14722070). In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity).
A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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