Sign in or Register   Sign in or Register
  |  

Mouse Anti-NACC1 Recombinant Antibody (6H2) (CBMAB-N1056-WJ)

This product is a Mouse antibody that recognizes NACC1. The antibody 6H2 can be used for immunoassay techniques such as: WB, IHC, ELISA.
See all NACC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6H2
Application
WB, IHC, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.03% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nucleus Accumbens Associated 1
Introduction
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]
Entrez Gene ID
112939
UniProt ID
Q96RE7
Alternative Names
Nucleus Accumbens Associated 1; Nucleus Accumbens Associated 1, BEN And BTB (POZ) Domain Containing; BTB/POZ Domain-Containing Protein 14B; BEN Domain Containing 8; BTBD14B; NAC-1; NAC1;
Function
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
Biological Process
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: Distribution in the cytoplasm is dependent on phosphorylation.
Involvement in disease
Neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination (NECFM):
A neurodevelopmental disorder characterized by microcephaly, profound developmental delay, intellectual disability, cataracts, severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand movements. Brain imaging reveals delayed myelination and cerebral atrophy.

Xie, Q., Tong, C., & Xiong, X. (2023). An overview of the co-transcription factor NACC1: Beyond its pro-tumor effects. Life Sciences, 122314.

Daniel, J. A., Elizarova, S., Shaib, A. H., Chouaib, A. A., Magnussen, H. M., Wang, J., ... & Tirard, M. (2023). An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission. Frontiers in Molecular Neuroscience, 16.

Ye, X., Song, H., Hu, H., Zhou, C., Chen, Q., Hong, L., ... & Zhu, H. (2022). MiR-361-3p alleviates cerebral ischemia–reperfusion injury by targeting NACC1 through the PINK1/Parkin pathway. Journal of Molecular Histology, 53(2), 357-367.

Cao, Z., Chen, H., Mei, X., & Li, X. (2021). Silencing of NACC1 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma cells via regulating the AKT/mTOR signaling pathway. Oncology Letters, 22(6), 1-8.

Argani, P., Palsgrove, D. N., Anders, R. A., Smith, S. C., Saoud, C., Kwon, R., ... & Antonescu, C. R. (2021). A novel NIPBL-NACC1 gene fusion is characteristic of the cholangioblastic variant of intrahepatic cholangiocarcinoma. The American journal of surgical pathology, 45(11), 1550-1560.

Yang, T., Shen, P., Chen, Q., Wu, P., Yuan, H., Ge, W., ... & Jiang, K. (2021). FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma. Journal of Experimental & Clinical Cancer Research, 40(1), 1-25.

Tao, H. F., Shen, J. X., Hou, Z. W., Chen, S. Y., Su, Y. Z., & Fang, J. L. (2021). lncRNA FOXP4‑AS1 predicts poor prognosis and accelerates the progression of mantle cell lymphoma through the miR‑423‑5p/NACC1 pathway. Oncology Reports, 45(2), 469-480.

Sun, Z. (2020). Circular RNA hsa_circ_0001588 promotes the malignant progression of lung adenocarcinoma by modulating miR-524-3p/NACC1 signaling. Life Sciences, 259, 118157.

Li, L., Yu, H., & Ren, Q. (2020). MiR-218-5p suppresses the progression of retinoblastoma through targeting NACC1 and inhibiting the AKT/mTOR signaling pathway. Cancer Management and Research, 6959-6967.

Yin, L., Sun, T., & Liu, R. (2020). NACC-1 regulates hepatocellular carcinoma cell malignancy and is targeted by miR-760. Acta Biochimica et Biophysica Sinica, 52(3), 302-309.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NACC1 Recombinant Antibody (6H2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare