Mouse Anti-NARFL Recombinant Antibody (E-7) (CBMAB-N1196-WJ)

This product is a Mouse antibody that recognizes NARFL. The antibody E-7 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NARFL antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

mouse, rat, Human

Clone

E-7

Application

WB, IP, IF, ELISA

Basic Information

Specificity

mouse, rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

nuclear prelamin A recognition factor-like

Introduction

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.

Entrez Gene ID

64428

UniProt ID

Q9H6Q4

Alternative Names

Nuclear Prelamin A Recognition Factor Like; Iron-Only Hydrogenase-Like Protein 1; Protein Related To Narf; IOP1; PRN; Nuclear Prelamin A Recognition Factor-Like Protein; Cytosolic Fe-S Cluster Assembly Factor NARFL;

Function

Biological Process

Hematopoietic progenitor cell differentiation Source: Ensembl
Iron-sulfur cluster assembly Source: UniProtKB
Oxygen homeostasis Source: HGNC-UCL
Regulation of gene expression Source: BHF-UCL
Response to hypoxia Source: HGNC-UCL

Cellular Location

CIA complex

References

Liu, H., Wu, X., Yang, T., Wang, C., Huang, F., Xu, Y., & Peng, J. (2023). NARFL deficiency caused mitochondrial dysfunction in lung cancer cells by HIF-1α–DNMT1 axis. Scientific Reports, 13(1), 17176.

Liu, H. Z., Peng, J., Zhao, M. Z., & Xu, Y. (2022). Deficiency of NARFL increases transcription of NADPH oxidases and ROS production impairing the function of endothelial cells. Life Sciences, 301, 120567.

Dong, Y., Zhang, C., Jin, L., Li, D., Chen, W., Huo, H., & Li, S. (2022). PMM2 and NARFL are paternally imprinted genes in bovines. Animal Genetics, 53(5), 592-598.

Luo, J., Zhang, X., He, S., Lou, Q., Zhai, G., Shi, C., ... & Zheng, F. (2020). Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox Biology, 28, 101355.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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