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Mouse Anti-NMU Recombinant Antibody (A-5) (CBMAB-N2834-WJ)

This product is a Mouse antibody that recognizes NMU. The antibody A-5 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NMU antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
A-5
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuromedin U
Introduction
This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
Entrez Gene ID
Mouse56183
Rat63887
UniProt ID
MouseQ9QXK8
RatP12760
Alternative Names
Neuromedin U; Prepro-NMU; Neuromedin U Precursor-Related Peptide/Neuromedin U Preproprotein; Neuromedin-U;
Function
Neuromedin-U-25
Ligand for receptors NMUR1 and NMUR2 (By similarity).
Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
Neuromedin precursor-related peptide 33
Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.
Neuromedin precursor-related peptide 36
Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
Biological Process
Energy homeostasisIEA:Ensembl
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of smooth muscle contractionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of feeding behaviorIEA:Ensembl
Regulation of grooming behaviorIEA:Ensembl
Temperature homeostasisIEA:Ensembl
Cellular Location
Secreted

Botticelli, L., Di Bonaventura, E. M., Del Bello, F., Giorgioni, G., Piergentili, A., Quaglia, W., ... & Di Bonaventura, M. V. M. (2023). The neuromedin U system: Pharmacological implications for the treatment of obesity and binge eating behavior. Pharmacological Research, 106875.

Pałasz, A., Worthington, J. J., Filipczyk, Ł., & Saganiak, K. (2023). Pharmacomodulation of brain neuromedin U signaling as a potential therapeutic strategy. Journal of Neuroscience Research, 101(11), 1728-1736.

Ye, Y., Luo, J., Zeng, N., Jiang, S., Chen, W., Hoyle, R. D., ... & Xue, L. (2022). Neuromedin U promotes human type 2 immune responses. Mucosal Immunology, 15(5), 990-999.

Sasaki-Hamada, S., Maeno, Y., Yabe, M., & Ishibashi, H. (2021). Neuromedin U modulates neuronal excitability in rat hippocampal slices. Neuropeptides, 89, 102168.

Ye, Y., Liang, Z., & Xue, L. (2021). Neuromedin U: potential roles in immunity and inflammation. Immunology, 162(1), 17-29.

Malendowicz, L. K., & Rucinski, M. (2021). Neuromedins NMU and NMS: an updated overview of their functions. Frontiers in Endocrinology, 12, 713961.

Teranishi, H., & Hanada, R. (2021). Neuromedin U, a key molecule in metabolic disorders. International journal of molecular sciences, 22(8), 4238.

Hsiao, Y. T., Jestes, K. J., Jackson, K. L., Zukosky, T., Squire, M. E., Hum, J. M., & Lowery, J. W. (2020). Neuromedin U (NMU) regulates osteoblast differentiation and activity. Biochemical and Biophysical Research Communications, 524(4), 890-894.

Przygodzka, P., Soboska, K., Sochacka, E., & Boncela, J. (2019). Neuromedin U: a small peptide in the big world of cancer. Cancers, 11(9), 1312.

Kuhre, R. E., Christiansen, C. B., Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, I. M., ... & Holst, J. J. (2019). Neuromedin U does not act as a decretin in rats. Cell Metabolism, 29(3), 719-726.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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