Mouse Anti-NMU Recombinant Antibody (A-5) (CBMAB-N2834-WJ)

Name: Mouse Anti-NMU Recombinant Antibody (A-5)
SKU: CBMAB-N2834-WJ
Rating: 5 (1 reviews)

See all NMU antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A-5

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neuromedin U

Introduction

This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

Entrez Gene ID

Mouse	56183
Rat	63887

UniProt ID

Mouse	Q9QXK8
Rat	P12760

Alternative Names

Neuromedin U; Prepro-NMU; Neuromedin U Precursor-Related Peptide/Neuromedin U Preproprotein; Neuromedin-U;

Function

Neuromedin-U-25
Ligand for receptors NMUR1 and NMUR2 (By similarity).
Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
Neuromedin precursor-related peptide 33
Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.
Neuromedin precursor-related peptide 36
Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.

Biological Process

Energy homeostasisIEA:Ensembl
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of smooth muscle contractionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of feeding behaviorIEA:Ensembl
Regulation of grooming behaviorIEA:Ensembl
Temperature homeostasisIEA:Ensembl

Cellular Location

Secreted

Botticelli, L., Di Bonaventura, E. M., Del Bello, F., Giorgioni, G., Piergentili, A., Quaglia, W., ... & Di Bonaventura, M. V. M. (2023). The neuromedin U system: Pharmacological implications for the treatment of obesity and binge eating behavior. Pharmacological Research, 106875.

Pałasz, A., Worthington, J. J., Filipczyk, Ł., & Saganiak, K. (2023). Pharmacomodulation of brain neuromedin U signaling as a potential therapeutic strategy. Journal of Neuroscience Research, 101(11), 1728-1736.

Ye, Y., Luo, J., Zeng, N., Jiang, S., Chen, W., Hoyle, R. D., ... & Xue, L. (2022). Neuromedin U promotes human type 2 immune responses. Mucosal Immunology, 15(5), 990-999.

Sasaki-Hamada, S., Maeno, Y., Yabe, M., & Ishibashi, H. (2021). Neuromedin U modulates neuronal excitability in rat hippocampal slices. Neuropeptides, 89, 102168.

Ye, Y., Liang, Z., & Xue, L. (2021). Neuromedin U: potential roles in immunity and inflammation. Immunology, 162(1), 17-29.

Malendowicz, L. K., & Rucinski, M. (2021). Neuromedins NMU and NMS: an updated overview of their functions. Frontiers in Endocrinology, 12, 713961.

Teranishi, H., & Hanada, R. (2021). Neuromedin U, a key molecule in metabolic disorders. International journal of molecular sciences, 22(8), 4238.

Hsiao, Y. T., Jestes, K. J., Jackson, K. L., Zukosky, T., Squire, M. E., Hum, J. M., & Lowery, J. W. (2020). Neuromedin U (NMU) regulates osteoblast differentiation and activity. Biochemical and Biophysical Research Communications, 524(4), 890-894.

Przygodzka, P., Soboska, K., Sochacka, E., & Boncela, J. (2019). Neuromedin U: a small peptide in the big world of cancer. Cancers, 11(9), 1312.

Kuhre, R. E., Christiansen, C. B., Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, I. M., ... & Holst, J. J. (2019). Neuromedin U does not act as a decretin in rats. Cell Metabolism, 29(3), 719-726.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-NMU Recombinant Antibody (A-5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry