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Mouse Anti-NR2F2 Antibody (1G3) (CBMAB-0756-YC)

Provided herein are mouse monoclonal antibodies against Human NR2F2. The antibody clone 1G3 can be used for immunoassay techniques, such as ELISA and IP.
See all NR2F2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Common fruit fly
Clone
1G3
Antibody Isotype
IgG2a
Application
ELISA, IP

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Common fruit fly
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NR2F2
Introduction
NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a ligand inducible transcription factor that is involved in the regulation of many different genes. NR2F2 is a member of the steroid thyroid hormone superfamily of nuclear receptors.
Entrez Gene ID
7026
UniProt ID
P24468
Alternative Names
ARP1; COUP-TFII; COUPTFB; NF-E3; SVP40; TFCOUP2
Function
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development (PubMed:29478779).
Biological Process
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Anterior/posterior pattern specificationIEA:Ensembl
Blood vessel morphogenesisIEA:Ensembl
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Female gonad developmentManual Assertion Based On ExperimentIMP:UniProtKB
FertilizationIEA:Ensembl
Forebrain developmentIEA:Ensembl
Limb developmentIEA:Ensembl
Lymphatic endothelial cell fate commitmentManual Assertion Based On ExperimentIMP:BHF-UCL
Maternal placenta developmentIEA:Ensembl
Negative regulation of cyclin-dependent protein serine/threonine kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Neuron migrationIEA:Ensembl
Placenta blood vessel developmentIEA:Ensembl
Positive regulation of systemic arterial blood pressureIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Radial pattern formationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to estradiolIEA:Ensembl
Skeletal muscle tissue developmentIEA:Ensembl
Trophoblast giant cell differentiationIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Congenital heart defects, multiple types, 4 (CHTD4):
A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions.
46,XX sex reversal 5 (SRXX5):
A condition in which male gonads develop in a genetic female (female to male sex reversal). Additional features in SRXX5 patients are congenital heart disease, congenital diaphragmatic hernia, and blepharophimosis-ptosis-epicanthus inversus syndrome. SRXX5 inheritance is autosomal dominant.

Oh, Y., Quiroz, E., Wang, T., Medina-Laver, Y., Dominguez, F., & Wu, S. P. (2023). The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy. Frontiers in Endocrinology, 14, 1229033.

Davalos, V., Lovell, C. D., Von Itter, R., Dolgalev, I., Agrawal, P., Baptiste, G., ... & Hernando, E. (2023). An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma. Nature communications, 14(1), 1867.

Ganapathi, M., Matsuoka, L. S., March, M., Li, D., Brokamp, E., Benito-Sanz, S., ... & Bhoj, E. (2023). Heterozygous rare variants in NR2F2 cause a recognizable multiple congenital anomaly syndrome with developmental delays. European Journal of Human Genetics, 31(10), 1117-1124.

Ma, L., Huang, M., Liao, X., Cai, X., & Wu, Q. (2022). NR2F2 Regulates Cell Proliferation and Immunomodulation in Whartons’ Jelly Stem Cells. Genes, 13(8), 1458.

Ghorbanzadeh, S., Poor-Ghassem, N., Afsa, M., Nikbakht, M., & Malekzadeh, K. (2022). Long non-coding RNA NR2F2-AS1: its expanding oncogenic roles in tumor progression. Human Cell, 35(5), 1355-1363.

Mauri, F., Schepkens, C., Lapouge, G., Drogat, B., Song, Y., Pastushenko, I., ... & Blanpain, C. (2021). NR2F2 controls malignant squamous cell carcinoma state by promoting stemness and invasion and repressing differentiation. Nature Cancer, 2(11), 1152-1169.

Jiang, Y., Liu, X., Shen, R., Gu, X., & Qian, W. (2021). Fbxo21 regulates the epithelial-to-mesenchymal transition through ubiquitination of Nr2f2 in gastric cancer. Journal of Cancer, 12(5), 1421.

Sissaoui, S., Yu, J., Yan, A., Li, R., Yukselen, O., Kucukural, A., ... & Lawson, N. D. (2020). Genomic characterization of endothelial enhancers reveals a multifunctional role for NR2F2 in regulation of arteriovenous gene expression. Circulation research, 126(7), 875-888.

Xia, B., Hou, L., Kang, H., Chang, W., Liu, Y., Zhang, Y., & Ding, Y. (2020). NR2F2 plays a major role in insulin-induced epithelial-mesenchymal transition in breast cancer cells. BMC cancer, 20, 1-12.

Kim, W., Giannikou, K., Dreier, J. R., Lee, S., Tyburczy, M. E., Silverman, E. K., ... & Kwiatkowski, D. J. (2019). A genome-wide association study implicates NR2F2 in lymphangioleiomyomatosis pathogenesis. European Respiratory Journal, 53(6).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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