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Mouse Anti-OSA Antibody (Osa) (CBMAB-0894-YC)


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Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
Osa
Antibody Isotype
IgG1, ĸ
Application
WB

Basic Information

Specificity
Common fruit fly
Antibody Isotype
IgG1, ĸ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
OSA
Introduction
OSA (CG7467 gene product from transcript CG7467-RE) is a nuclear protein that is a component of the Brahma chromatin-remodeling complex in Drosophila melanogaster. OSA is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation.
Entrez Gene ID
42130
UniProt ID
Q8IN94
Alternative Names
Anon-WO0118547.314; anon-WO0172774.126; C819; CG7467; Dmel\CG7467; E(E2F)3C; eld; en(lz)4F/4H; eyelid; l(3)00090; l(3)04539; l(3)j9C3; Osa; OSA; p300
Function
Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Required for the activation of genes such as Antp, Ubx and Eve. Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins. Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. Acts as an essential coactivator for Zeste, which recruits the whole complex to specific genes. In contrast, it acts as a corepressor for Wg target genes, possibly via an interaction with Pan and Gro. It also acts as a negative regulator for proneural achaete-scute, when it is directly recruited by Pan and Chi. Also represses E2f activation.
Biological Process
Chromatin remodelingIEA:InterPro
Imaginal disc-derived leg morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Imaginal disc-derived wing margin morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Imaginal disc-derived wing morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Imaginal disc-derived wing vein morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of neuroblast proliferationManual Assertion Based On ExperimentIGI:FlyBase
Neuroblast fate commitmentManual Assertion Based On ExperimentIMP:FlyBase
Photoreceptor cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:FlyBase
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:FlyBase
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Segment specificationManual Assertion Based On ExperimentIMP:UniProtKB
Wing disc dorsal/ventral pattern formationManual Assertion Based On ExperimentIGI:FlyBase
Wnt signaling pathwayManual Assertion Based On Experiment
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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