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Mouse Anti-PAX4 Recombinant Antibody (2F3) (CBMAB-P0869-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F3
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-228 of human PAX4 (NP_006184) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-228

Target

Full Name
Paired Box 4
Introduction
PAX4 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
Entrez Gene ID
5078
UniProt ID
O43316
Alternative Names
Paired Box 4; Paired Box Gene 4; Paired Box Protein Pax-4; Paired Domain Gene 4; MODY9; KPD;
Function
Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.
Biological Process
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell differentiationIEA:UniProtKB-KW
Pancreas developmentIEA:InterPro
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Diabetes mellitus, non-insulin-dependent (NIDDM):
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Diabetes mellitus, insulin-dependent (IDDM):
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Diabetes mellitus, ketosis-prone (KPD):
An atypical form of diabetes mellitus characterized by an acute initial presentation with severe hyperglycemia and ketosis, as seen in classic type 1 diabetes, but after initiation of insulin therapy, prolonged remission is often possible with cessation of insulin therapy and maintenance of appropriate metabolic control. Metabolic studies show a markedly blunted insulin secretory response to glucose, partially reversible with the improvement of blood glucose control. Variable levels of insulin resistance are observed, especially in obese patients. Pancreatic beta-cell autoimmunity is a rare finding.
Maturity-onset diabetes of the young 9 (MODY9):
A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
More Infomation

Teerawattanapong, N., Srisawat, L., Narkdontri, T., Yenchitsomanus, P. T., Tangjittipokin, W., & Plengvidhya, N. (2024). The effects of transcription factor 7-like 2 rs7903146 and paired box 4 rs2233580 variants associated with type 2 diabetes on the therapeutic efficacy of hypoglycemic agents. Heliyon.

Ko, J., Fonseca, V. A., & Wu, H. (2023). Pax4 in health and diabetes. International Journal of Molecular Sciences, 24(9), 8283.

Kamal, M. M., Islam, M. N., Rabby, M. G., Zahid, M. A., & Hasan, M. M. (2023). In Silico Functional and Structural Analysis of Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) in Human Paired Box 4 Gene. Biochemical Genetics, 1-24.

Narayan, G., Agrawal, A., Sen, P., Nagotu, S., & Thummer, R. P. (2023). Production of Bioactive Human PAX4 Protein from E. coli. The Protein Journal, 42(6), 766-777.

Lee, Y. L., Ting, T. H., Lim, C. T., Arrumugam-Arthini, C., Karuppiah, T., & Ling, K. H. (2023). Novel PAX4 variant in a child and family with diabetes mellitus–case report and review of the literature. Journal of Pediatric Endocrinology and Metabolism, 36(10), 988-992.

Zhang, D., Chen, C., Yang, W., Piao, Y., Ren, L., & Sang, Y. (2022). C. 487C> T mutation in PAX4 gene causes MODY9: A case report and literature review. Medicine, 101(51), e32461.

Zhang, Y., Ding, L., Ni, Q., Tao, R., & Qin, J. (2021). Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis. Aging (Albany NY), 13(12), 16786.

Zhang, T., Wang, H., Wang, T., Wei, C., Jiang, H., Jiang, S., ... & Ma, L. (2019). Pax4 synergistically acts with Pdx1, Ngn3 and MafA to induce HuMSCs to differentiate into functional pancreatic β‑cells. Experimental and therapeutic medicine, 18(4), 2592-2598.

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For research use only. Not intended for any clinical use.

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