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Mouse Anti-PC Recombinant Antibody (3H2AD9) (CBMAB-P0942-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3H2AD9
Antibody Isotype
IgG1, κ
Application
ELISA, ICC, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
HEPES, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pyruvate Carboxylase
Introduction
PC is pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
Entrez Gene ID
5091
UniProt ID
P11498
Alternative Names
Pyruvate Carboxylase; Pyruvic Carboxylase; EC 6.4.1.1; PCB; Pyruvate Carboxylase, Mitochondrial; EC 6.4.1;
Function
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Biological Process
GluconeogenesisManual Assertion Based On ExperimentIBA:GO_Central
Lipid metabolic processIEA:UniProtKB-KW
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:AgBase
Positive regulation by host of viral processManual Assertion Based On ExperimentIMP:AgBase
Pyruvate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Viral release from host cellManual Assertion Based On ExperimentIMP:AgBase
Viral RNA genome packagingManual Assertion Based On ExperimentIMP:AgBase
Cellular Location
Mitochondrion matrix
Involvement in disease
Pyruvate carboxylase deficiency (PC deficiency):
Leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.
PTM
Acetylation of Lys-748 might play a role in catalytic activity regulation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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