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Mouse Anti-PTF1A Recombinant Antibody (V2-13225) (CBMAB-1715-CN)

This product is a mouse antibody that recognizes PTF1A of human. The antibody 1A2 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all PTF1A antibodies
Published Data
Fig.1 The C-terminal domain of Ptf1a interacts with ICAT.
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Fig.2 ICAT reduces the binding of Rbpjl to Ptf1a, but it does not affect its subcellular distribution.
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Fig.3 Identification of sequences regulatingPtf1aexpression.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-13225
Antibody Isotype
IgG2a
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant fragment (GST-tag) corresponding to Human PTF1A aa. 250-328.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pancreas specific transcription factor, 1a
Introduction
This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. This protein plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates.
Entrez Gene ID
256297
UniProt ID
Q7RTS3
Alternative Names
p48; PACA; PAGEN2; bHLHa29; PTF1-p48
Function
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
Biological Process
Amacrine cell differentiationISS:UniProtKB
Cerebellum developmentManual Assertion Based On ExperimentIMP:UniProtKB
Developmental processManual Assertion Based On ExperimentIBA:GO_Central
Exocrine pancreas developmentISS:UniProtKB
Neuron fate commitmentIEA:Ensembl
Pancreas developmentManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of neural retina developmentISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedISS:UniProtKB
Retina layer formationISS:UniProtKB
Retinoic acid receptor signaling pathwayIEA:Ensembl
Tissue developmentManual Assertion Based On ExperimentIDA:UniProtKB
Transcription by RNA polymerase IIIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity).
Involvement in disease
Pancreatic and cerebellar agenesis (PACA):
A disease characterized by neonatal diabetes mellitus, cerebellar agenesis or hypoplasia, severe intrauterine growth retardation, the presence of very little subcutaneous fat, and dysmorphic facial features.
Pancreatic agenesis 2 (PAGEN2):
A disease characterized by isolated hypoplasia or agenesis of the pancreas, pancreatic beta-cell failure resulting in neonatal insulin-dependent diabetes mellitus, and exocrine pancreatic insufficiency.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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