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Mouse Anti-PTPN23 Recombinant Antibody (CBFYH-3638) (CBMAB-H4197-FY)

This product is mouse antibody that recognizes PTPN23. The antibody CBFYH-3638 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all PTPN23 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYH-3638
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein tyrosine phosphatase, non-receptor type 23
Introduction
This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family.
Entrez Gene ID
Human25930
Mouse104831
Rat117552
UniProt ID
HumanQ9H3S7
MouseQ6PB44
RatO88902
Alternative Names
HDPTP; HD-PTP; PTP-TD14
Function
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351).
May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552).
Plays a role in ciliogenesis (PubMed:20393563).
Biological Process
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Early endosome to late endosome transportManual Assertion Based On ExperimentIMP:FlyBase
Endocytic recyclingManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of adherens junction organizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of homophilic cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of Wnt protein secretionManual Assertion Based On ExperimentIMP:FlyBase
Protein dephosphorylationIEA:InterPro
Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIBA:GO_Central
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Cytoplasmic vesicle
Endosome
Cytoplasm, cytoskeleton, cilium basal body
Early endosome
Involvement in disease
Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity (NEDBASS):
An autosomal recessive disorder characterized by global developmental delay, brain abnormalities, mainly ventriculomegaly and/or brain atrophy, intellectual disability, absent speech, peripheral spasticity, and microcephaly. Additional variable features include early-onset seizures, optic atrophy, and dysmorphic facial features. Early death may occur.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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