Mouse Anti-PTPN23 Recombinant Antibody (CBFYH-3638) (CBMAB-H4197-FY)

Name: Mouse Anti-PTPN23 Recombinant Antibody (CBFYH-3638)
SKU: CBMAB-H4197-FY
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBFYH-3638

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

protein tyrosine phosphatase, non-receptor type 23

Introduction

This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family.

Entrez Gene ID

Human	25930
Mouse	104831
Rat	117552

UniProt ID

Human	Q9H3S7
Mouse	Q6PB44
Rat	O88902

Alternative Names

HDPTP; HD-PTP; PTP-TD14

Function

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351).
May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552).
Plays a role in ciliogenesis (PubMed:20393563).

Biological Process

Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Early endosome to late endosome transportManual Assertion Based On ExperimentIMP:FlyBase
Endocytic recyclingManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of adherens junction organizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of early endosome to late endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of homophilic cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of Wnt protein secretionManual Assertion Based On ExperimentIMP:FlyBase
Protein dephosphorylationIEA:InterPro
Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIBA:GO_Central
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Cytoplasm
Cytoplasmic vesicle
Endosome
Cytoplasm, cytoskeleton, cilium basal body
Early endosome

Involvement in disease

Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity (NEDBASS):
An autosomal recessive disorder characterized by global developmental delay, brain abnormalities, mainly ventriculomegaly and/or brain atrophy, intellectual disability, absent speech, peripheral spasticity, and microcephaly. Additional variable features include early-onset seizures, optic atrophy, and dysmorphic facial features. Early death may occur.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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