Mouse Anti-RGS10 Recombinant Antibody (1G9-2D4) (CBMAB-R2424-CN)

Name: Mouse Anti-RGS10 Recombinant Antibody (1G9-2D4)
SKU: CBMAB-R2424-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1G9-2D4

Application

ELISA

Immunogen

Full length recombinant corresponding to human RGS10, aa. 1-182 (H09361) with GST tag

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

regulator of G-protein signaling 10

Introduction

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

6001

UniProt ID

O43665

Alternative Names

Regulator Of G Protein Signaling 10; Regulator Of G-Protein Signalling 10; Regulator Of G-Protein Signaling 10;

Function

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541).
Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111).
Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).

Biological Process

Biological Process G protein-coupled acetylcholine receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Isoform 1
Cytoplasm, cytosol
Nucleus
Forskolin treatment promotes phosphorylation and translocation to the nucleus.
Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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