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Mouse Anti-RGS10 Recombinant Antibody (1G9-2D4) (CBMAB-R2424-CN)

This product is a Mouse antibody that recognizes RGS10. The antibody 1G9-2D4 can be used for immunoassay techniques such as: ELISA.
See all RGS10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G9-2D4
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Full length recombinant corresponding to human RGS10, aa. 1-182 (H09361) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
regulator of G-protein signaling 10
Introduction
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6001
UniProt ID
O43665
Alternative Names
Regulator Of G Protein Signaling 10; Regulator Of G-Protein Signalling 10; Regulator Of G-Protein Signaling 10;
Function
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541).
Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111).
Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).
Biological Process
Biological Process G protein-coupled acetylcholine receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Cytoplasm, cytosol
Nucleus
Forskolin treatment promotes phosphorylation and translocation to the nucleus.
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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