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Mouse Anti-RHCE Recombinant Antibody (1V008) (CBMAB-R2504-CN)

This product is a Mouse antibody that recognizes RHCE. The antibody 1V008 can be used for immunoassay techniques such as: ELISA, FC, IHC, IP, WB.
See all RHCE antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1V008
Application
ELISA, FC, IHC, IP, WB

Basic Information

Immunogen
Peripheral blood lymphocytes from hyperimmune anti-C donor transformed by Epstein-Barr virus
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.3M NaCl, 1.25mM EDTA, before the addition of Glycerol to 40%
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
Rh Blood Group CcEe Antigens
Introduction
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Aug 2016]
Entrez Gene ID
6006
UniProt ID
P18577
Alternative Names
Rh Blood Group CcEe Antigens; Rhesus C/E Antigens; Rh Polypeptide 1; RH30A; RHIXB; RHPI; Rhe; RHC; RHCE Blood Group Variant Crawford Antigen Rh43; (C)Ces Type 1 Rhesus Blood Group D Antigen; Rhesus Blood Group Antigen, RhC Antigen; Silenced Rh Blood Group CcEe Antigen; Rhesus Blood Group Little E Antigen; Rhesus System C And E Polypeptides; Rhesus Blood Group, CcEe Antigens; Rhesus Blood Group Rhce Antigen; Blood Group Rh(CE) Polypeptide; Rhesus Blood Group CE Protein; Rh Blood Group Antigen Evans; Rhesus Blood Group E Antigen;
Function
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Biological Process
Biological Process ammonium homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ammonium transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Involvement in disease
Rh-null, amorph type (RHNA):
An autosomal recessive condition characterized by red blood cells that lack all Rh antigens, have increased osmotic fragility, diminished lifespan, and show changes in morphology resulting in stomatocytosis. Rh-null individuals have mild to moderate hemolytic anemia. They are at risk of having adverse reactions in response to transfusion or pregnancy, because they may produce antibodies against several of the Rh antigens.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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