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Mouse Anti-RIPK4 Recombinant Antibody (CBCNR-533) (CBMAB-R2760-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-533
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IHC-P, WB

Basic Information

Immunogen
RIPK4 (NP_065690, aa. 675-784) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
receptor interacting serine/threonine kinase 4
Introduction
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Entrez Gene ID
54101
UniProt ID
P57078
Alternative Names
Receptor Interacting Serine/Threonine Kinase 4; PKC-Delta-Interacting Protein Kinase; Ankyrin Repeat Domain-Containing Protein 3; Protein Kinase C-Associated Kinase; EC 2.7.11.1; ANKRD3; DIK; Receptor-Interacting Serine/Threonine-Protein Kinase 4; Receptor-Interacting Serine-Threonine Kinase 4;
Research Area
Signal transduction
Function
Serine/threonine protein kinase (By similarity).
Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity).
It is a direct transcriptional target of TP63 (PubMed:22197488).
Plays a role in NF-kappa-B activation (PubMed:12446564).
Biological Process
Morphogenesis of an epithelium
Positive regulation of NF-kappaB transcription factor activity
Skin development
Cellular Location
Cytoplasm
Membrane
Involvement in disease
Bartsocas-Papas syndrome (BPS):
An autosomal recessive disorder characterized by multiple popliteal pterygia leading to severe arthrogryposis, ankyloblepharon filiforme adnatum, filiform bands between the jaws, synostosis of the carpal/tarsal and phalangeal bones in the hands and feet, digital hypoplasia/aplasia, complete soft-tissue syndactyly, lack of nails, lack of scalp hair, eyebrows and eyelashes, blepharophimosis, cleft lip and/or palate, and hypoplastic external genitalia. Early lethality is common, although survival into childhood and beyond has been reported.
CHAND syndrome (CHANDS):
An autosomal recessive syndrome characterized by ankyloblepharon, sparse, curly and woolly hair, nail dysplasia, and oral frenula.
PTM
May be phosphorylated by MAP3K2 and MAP3K3.
Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426.
Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
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For research use only. Not intended for any clinical use.

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