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Mouse Anti-RORB Recombinant Antibody (H3925) (CBMAB-1779-CN)

This product is a mouse antibody that recognizes RORB of human. The antibody H3925 can be used for immunoassay techniques such as: ELISA, IHC-P, IP, WB.
See all RORB antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
H3925
Antibody Isotype
IgG2a
Application
ELISA, IHC-P, IP, WB

Basic Information

Immunogen
Recombinant fragment, corresponding to aa. 136-236 of Human ROR alpha + beta + gamma
Specificity
Human, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RAR-related orphan receptor B
Introduction
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The protein may act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. The protein may play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).
Entrez Gene ID
Human6096
Rat309288
UniProt ID
HumanQ92753
RatP45446
Alternative Names
RZRB; NR1F2; ROR-BETA; RZR-BETA; bA133M9.1
Function
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).
Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity).
Biological Process
Biological Process amacrine cell differentiationISS:UniProtKB
Biological Process cellular response to retinoic acidISS:UniProtKB
Biological Process eye photoreceptor cell developmentISS:UniProtKB
Biological Process negative regulation of osteoblast differentiationISS:UniProtKB
Biological Process negative regulation of transcription, DNA-templatedISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedISS:UniProtKB
Biological Process regulation of circadian rhythmISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Biological Process retina development in camera-type eyeISS:UniProtKB
Biological Process retinal cone cell developmentISS:UniProtKB
Biological Process retinal rod cell developmentISS:UniProtKB
Biological Process rhythmic processIEA:UniProtKB-KW
Biological Process visual perceptionIEA:UniProtKB-KW
Cellular Location
Nucleus, nucleoplasm
Involvement in disease
Epilepsy, idiopathic generalized 15 (EIG15):
An autosomal dominant form of idiopathic generalized epilepsy, a disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Seizure types include juvenile myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. EIG15 is characterized by onset of variable types of seizures in the first decade of life.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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