Mouse Anti-SCRIB Recombinant Antibody (CBXS-5871) (CBMAB-S0723-CQ)

Scribbled Planar Cell Polarity Protein

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Scribbled Planar Cell Polarity Protein; Vartul; CRIB1; SCRB1; Scribbled Homolog (Drosophila); Protein Scribble Homolog; Scribbled Homolog;

Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:19041750, PubMed:18716323, PubMed:18641685, PubMed:16965391, PubMed:27380321).
Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity).
Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750).
May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750).
May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323, PubMed:18641685).
May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672).
Functions as an activator of Rac GTPase activity.

Activation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Apoptotic process involved in morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Astrocyte cell migrationIEA:Ensembl
Auditory receptor cell stereocilium organizationIEA:Ensembl
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Cell-cell adhesionManual Assertion Based On ExperimentIGI:UniProtKB
Cochlear nucleus developmentIEA:Ensembl
Establishment of apical/basal cell polarityManual Assertion Based On ExperimentIMP:UniProtKB
Establishment of T cell polarityISS:UniProtKB
Establishment or maintenance of epithelial cell apical/basal polarityManual Assertion Based On ExperimentIBA:GO_Central
Mammary gland duct morphogenesisISS:UniProtKB
Negative regulation of activated T cell proliferationISS:UniProtKB
Negative regulation of mitotic cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Neural tube closureManual Assertion Based On ExperimentIMP:UniProtKB
Neurotransmitter receptor transport postsynaptic membrane to endosomeManual Assertion Based On ExperimentIBA:GO_Central
Neurotransmitter receptor transport, endosome to postsynaptic membraneManual Assertion Based On ExperimentIBA:GO_Central
Polarized epithelial cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Positive chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interferon-gamma productionISS:UniProtKB
Positive regulation of receptor recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Post-anal tail morphogenesisIEA:Ensembl
Protein localization to adherens junctionManual Assertion Based On ExperimentIMP:BHF-UCL
Receptor clusteringManual Assertion Based On ExperimentIBA:GO_Central
Receptor localization to synapseManual Assertion Based On ExperimentIBA:GO_Central
Regulation of postsynaptic neurotransmitter receptor internalizationIEA:Ensembl
Synaptic vesicle endocytosisIEA:Ensembl
Synaptic vesicle targetingIEA:Ensembl
Wound healingIEA:Ensembl

Cell membrane
Cell junction
Cell junction, adherens junction
Cell projection, lamellipodium
Cytoplasm
Cell junction, synapse, postsynapse
Cell junction, synapse, presynapse
Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity).

Neural tube defects (NTD):
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.

Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
Palmitoylated (PubMed:27380321).
Could be depalmitoylated by LYPLA1 and/or LYPLA2 (PubMed:27380321).
Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation (PubMed:27380321).