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Mouse Anti-SELENOS Recombinant Antibody (CBT2423) (V2LY-0625-LY561)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2423
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Purified recombinant fragment of human VIMP (AA: 1-187) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Selenoprotein S
Entrez Gene ID
55829
Function
Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
Biological Process
Biological Process cell redox homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to insulin stimulusManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process endoplasmic reticulum unfolded protein responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ER overload responseManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process establishment of protein localizationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process negative regulation of acute inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of glucose importManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process negative regulation of glycogen biosynthetic processManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process negative regulation of inflammatory response1 PublicationIC:BHF-UCL
Biological Process negative regulation of interleukin-6 productionISS:BHF-UCL
Biological Process negative regulation of macrophage apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of nitric-oxide synthase biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of tumor necrosis factor productionISS:BHF-UCL
Biological Process regulation of gluconeogenesisManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process regulation of nitric oxide metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to glucoseManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process response to redox stateManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retrograde protein transport, ER to cytosolManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Cytoplasm
Topology
Helical: 28-48
PTM
Truncated SELENOS proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) and CRL2(KLHDC3) complexes, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOS proteins (PubMed:26138980, PubMed:30526872).
Truncated SELENOS proteins produced by failed UGA/Sec decoding are also ubiquitinated by the CRL5(KLHDC1) complex (PubMed:32200094).
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For research use only. Not intended for any clinical use.

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