Mouse Anti-SLC25A20 Recombinant Antibody (CBXS-5503) (CBMAB-S2712-CQ)

Name: Mouse Anti-SLC25A20 Recombinant Antibody (CBXS-5503)
SKU: CBMAB-S2712-CQ
Rating: 5 (1 reviews)

See all SLC25A20 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-5503

Application

ELISA, IF

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

solute carrier family 25 (carnitine/acylcarnitine translocase), member 20

Introduction

This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants.

Entrez Gene ID

788

UniProt ID

O43772

Alternative Names

Solute Carrier Family 25 Member 20; Solute Carrier Family 25 (Carnitine/Acylcarnitine Translocase), Member 20; Carnitine/Acylcarnitine Translocase; CACT; CAC; Mitochondrial Carnitine/Acylcarnitine Carrier Protein; Carnitine-Acylcarnitine Carrier;

Function

Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (PubMed:12892634, PubMed:18307102) (Probable). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102).

Biological Process

Biological Process carnitine shuttleTAS:Reactome
Biological Process carnitine transmembrane transportISS:UniProtKB
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process mitochondrial transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Carnitine-acylcarnitine translocase deficiency (CACTD):
A rare long-chain fatty acid oxidation disorder. Metabolic consequences include hypoketotic hypoglycemia under fasting conditions, hyperammonemia, elevated creatine kinase and transaminases, dicarboxylic aciduria, very low free carnitine and abnormal acylcarnitine profile with marked elevation of the long-chain acylcarnitines. Clinical features include neurologic abnormalities, cardiomyopathy, arrhythmias, skeletal muscle damage, liver dysfunction and episodes of life-threatening coma, which eventually lead to death. Most patients become symptomatic in the neonatal period with a rapidly progressive deterioration and a high mortality rate.

Topology

Cytoplasmic: 2-12
Helical: 13-31
Mitochondrial matrix: 32-73
Helical: 74-93
Cytoplasmic: 94-112
Helical: 113-131
Mitochondrial matrix: 132-170
Helical: 171-190
Cytoplasmic: 191-211
Helical: 212-230
Mitochondrial matrix: 231-267
Helical: 268-287
Cytoplasmic: 288-301

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SLC25A20 Recombinant Antibody (CBXS-5503)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SLC25A20 Recombinant Antibody (CBXS-0443) (CAT#: CBMAB-S3393-CQ)

Mouse Anti-SLC25A20 Recombinant Antibody (CBXS-0442) (CAT#: CBMAB-S3392-CQ)

Mouse Anti-SLC25A20 Recombinant Antibody (CBXS-0441) (CAT#: CBMAB-S3391-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry