Sign in or Register   Sign in or Register
  |  

Mouse Anti-SLC52A2 Recombinant Antibody (6A7H10) (CBMAB-G6592-LY)

This product is antibody recognizes SLC52A2. The antibody 6A7H10 immunoassay techniques such as: ELISA, WB.
See all SLC52A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6A7H10
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Purified recombinant fragment of PAR1 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier protein 52, member 2
Introduction
This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia. [provided by RefSeq, Jul 2012]
Entrez Gene ID
79581
UniProt ID
Q9HAB3
Alternative Names
Solute Carrier Family 52 Member 2; Solute Carrier Family 52 (Riboflavin Transporter); Member 2; Porcine Endogenous Retrovirus A Receptor 1; G Protein-Coupled Receptor 172A; Riboflavin Transporter 3; PERV-A Receptor 1; GPR172A; HRFT3; PAR1;
Function
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22864630, PubMed:23243084, PubMed:24253200, PubMed:27702554).
Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145).
May also act as a receptor for 4-hydroxybutyrate (Probable).
(Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
Biological Process
Biological Process riboflavin metabolic processTAS:Reactome
Biological Process riboflavin transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Brown-Vialetto-Van Laere syndrome 2 (BVVLS2):
An autosomal recessive progressive neurologic disorder characterized by early childhood onset of sensorineural deafness, bulbar dysfunction, and severe diffuse muscle weakness and wasting resulting in respiratory insufficiency and loss of independent ambulation. Because it results from a defect in riboflavin metabolism, some patients may benefit from high-dose riboflavin supplementation.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SLC52A2 Recombinant Antibody (6A7H10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare