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Rabbit Anti-SRGAP1 Monoclonal Antibody (EPR8760(2)) (CBMAB-1548-YC)

Provided herein is a rabbit monoclonal antibody against Human SRGAP1. The antibody, clone EPR8760(2), can be used for immunoassay techniques, such as IHC-P, ICC, IF, FC and WB.
See all SRGAP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR8760(2)
Antibody Isotype
IgG
Application
IHC-P, ICC, IF, FC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to Human SRGAP1 aa 1050 to the C-terminus (C terminal).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLIT-ROBO Rho GTPase activating protein 1
Introduction
SRGAP1 is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42.
Entrez Gene ID
Human57522
Mouse117600
Rat314903
UniProt ID
HumanQ7Z6B7
MouseQ91Z69
RatF1M287
Alternative Names
NMTC2; ARHGAP13
Function
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Biological Process
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionIEA:InterPro
Cellular Location
cytoplasm
cytosol
Involvement in disease
Thyroid cancer, non-medullary, 2 (NMTC2):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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