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Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-3287) (CBMAB-S6027-CQ)

This product is a mouse antibody that recognizes SRGAP1. The antibody CBXS-3287 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all SRGAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3287
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa952-1051 from human SRGAP1 (NP_065813) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLIT-ROBO Rho GTPase activating protein 1
Introduction
The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42.
Entrez Gene ID
57522
UniProt ID
Q7Z6B7
Alternative Names
SLIT-ROBO Rho GTPase Activating Protein 1; Rho GTPase-Activating Protein 13; ARHGAP13; SLIT-ROBO Rho GTPase-Activating Protein 1; KIAA1304; SrGAP1; NMTC2;
Function
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Biological Process
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionIEA:InterPro
Cellular Location
cytoplasm
cytosol
Involvement in disease
Thyroid cancer, non-medullary, 2 (NMTC2):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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