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Mouse Anti-SRGAP1 Recombinant Antibody (5D2) (CBMAB-A8593-LY)

The product is antibody recognizes SRGAP1. The antibody 5D2 immunoassay techniques such as: WB, ELISA.
See all SRGAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
5D2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SRGAP1 (NP_065813, 952 a.a. ~ 1050 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SLIT-ROBO Rho GTPase activating protein 1
Entrez Gene ID
Human57522
Mouse117600
UniProt ID
HumanQ7Z6B7
MouseQ91Z69
Alternative Names
ARHGAP13; FLJ22166; KIAA1304
Function
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Biological Process
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionIEA:InterPro
Cellular Location
cytoplasm
cytosol
Involvement in disease
Thyroid cancer, non-medullary, 2 (NMTC2):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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