SRGAP1

The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42.
Full Name
SLIT-ROBO Rho GTPase activating protein 1
Function
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Biological Process
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionIEA:InterPro
Cellular Location
cytoplasm
cytosol
Involvement in disease
Thyroid cancer, non-medullary, 2 (NMTC2):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
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Anti-SRGAP1 antibodies

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Mouse Anti-SRGAP1 Recombinant Antibody (5D2) (CBMAB-A8593-LY)

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Target: SRGAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 5D2
Application*: WB, E
Datasheet SDS

Mouse Anti-SRGAP1 Recombinant Antibody (5D10) (CBMAB-A8592-LY)

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Target: SRGAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5D10
Application*: WB, E
Datasheet SDS

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-3287) (CBMAB-S6027-CQ)

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Target: SRGAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3287
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-3284) (CBMAB-S6024-CQ)

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Target: SRGAP1
Host: Mouse
Specificity: Human
Clone: CBXS-3284
Application*: E, IF, WB
Datasheet SDS

Rabbit Anti-SRGAP1 Recombinant Antibody (CBXS-1616) (CBMAB-S4465-CQ)

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Target: SRGAP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1616
Application*: WB, P, F, IF
Datasheet SDS

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-0710) (CBMAB-S3643-CQ)

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Target: SRGAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBXS-0710
Application*: IF, SE, E, WB
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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