SRGAP1

The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42.

Full Name

SLIT-ROBO Rho GTPase activating protein 1

Function

GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Biological Process

Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionIEA:InterPro

Cellular Location

cytoplasm
cytosol

Involvement in disease

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Anti-SRGAP1 antibodies

Rabbit Anti-SRGAP1 Monoclonal Antibody (EPR8760(2)) (CBMAB-1548-YC)

Datasheet

SDS

Target: SRGAP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EPR8760(2)

Application*: P, IC, IF, F, WB

Mouse Anti-SRGAP1 Recombinant Antibody (5D2) (CBMAB-A8593-LY)

Datasheet

SDS

Target: SRGAP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: 5D2

Application*: WB, E

Mouse Anti-SRGAP1 Recombinant Antibody (5D10) (CBMAB-A8592-LY)

Datasheet

SDS

Target: SRGAP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5D10

Application*: WB, E

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-3287) (CBMAB-S6027-CQ)

Datasheet

SDS

Target: SRGAP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3287

Application*: E, IH, WB

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-3284) (CBMAB-S6024-CQ)

Datasheet

SDS

Target: SRGAP1

Host: Mouse

Specificity: Human

Clone: CBXS-3284

Application*: E, IF, WB

Rabbit Anti-SRGAP1 Recombinant Antibody (CBXS-1616) (CBMAB-S4465-CQ)

Datasheet

SDS

Target: SRGAP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1616

Application*: WB, P, F, IF

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-0710) (CBMAB-S3643-CQ)

Datasheet

SDS

Target: SRGAP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: CBXS-0710

Application*: IF, SE, E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)