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SRGAP1

The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42.

Full Name

SLIT-ROBO Rho GTPase activating protein 1

Function

GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Biological Process

Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionIEA:InterPro

Cellular Location

cytoplasm
cytosol

Involvement in disease

Thyroid cancer, non-medullary, 2 (NMTC2):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.

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Anti-SRGAP1 antibodies

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Mouse Anti-SRGAP1 Recombinant Antibody (5D2) (CBMAB-A8593-LY)

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Target: SRGAP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: 5D2

Application*: WB, E

Mouse Anti-SRGAP1 Recombinant Antibody (5D10) (CBMAB-A8592-LY)

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Target: SRGAP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5D10

Application*: WB, E

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-3287) (CBMAB-S6027-CQ)

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Target: SRGAP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3287

Application*: E, IH, WB

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-3284) (CBMAB-S6024-CQ)

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Target: SRGAP1

Host: Mouse

Specificity: Human

Clone: CBXS-3284

Application*: E, IF, WB

Rabbit Anti-SRGAP1 Recombinant Antibody (CBXS-1616) (CBMAB-S4465-CQ)

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Target: SRGAP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1616

Application*: WB, P, F, IF

Mouse Anti-SRGAP1 Recombinant Antibody (CBXS-0710) (CBMAB-S3643-CQ)

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Target: SRGAP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: CBXS-0710

Application*: IF, SE, E, WB

More Infomation

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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