Mouse Anti-TBC1D4 Recombinant Antibody (CBT2626) (V2LY-0625-LY961)

Name: Mouse Anti-TBC1D4 Recombinant Antibody (CBT2626)
SKU: V2LY-0625-LY961
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-TBC1D4 Recombinant Antibody (CBT2626) (V2LY-0625-LY961) in ELISA

Mouse Anti-TBC1D4 Recombinant Antibody (CBT2626) (V2LY-0625-LY961) in WB

Mouse Anti-TBC1D4 Recombinant Antibody (CBT2626) (V2LY-0625-LY961) in FC

Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2626

Application

Immunogen

Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TBC1D4 Gene(Protein Coding) TBC1 Domain Family Member 4

Entrez Gene ID

9882

Function

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Biological Process

Biological Process activation of GTPase activityIBA:GO_Central1 Publication
Biological Process cellular response to insulin stimulusIMP:UniProtKB1 Publication
Biological Process negative regulation of vesicle fusionIEA:Ensembl
Biological Process vesicle-mediated transportIMP:UniProtKB1 Publication

Cellular Location

Cytoplasm
Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.

Involvement in disease

Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5):
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

PTM

Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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